Aims: To prospectively explore the association between sedentary time (SED-time) and the development of diabetic foot ulcer (DFU) in people with diabetic peripheral neuropathy (DPN). Methods: 175 DPN individuals who attended the annual evaluation for the SAMBA Study (2012–2019) were included. Main outcome measure was the first diagnosis of DFU. SED-time was measured by the PAS 2.1 questionnaire. Nerve function was evaluated by nerve conduction studies. Vascular function was assessed by Ankle-brachial index (ABI) and pedal pulses. Foot deformity and skin dryness were examined by visual inspection. Results: 62 participants (35.5%) developed a DFU during the study. SED-time was significantly higher in people who developed DFUs (12.8 ± 3.0 vs 9.4 ± 3.1 h/day). Logistic regression showed that among several nervous (motor amplitude, OR 0.33, 95% CI, 0.18–0.60; sensory amplitude, 0.85, 0.77–0.94) and vascular parameters (ABI, 0.23, 0.1–0.61; pedal pulses, 2.81, 0.12–0.63) and foot characteristics (deformity, 2.63, 1.30–5.32; skin dryness, 2.04, 0.95–4.37), SED-time was one of the strongest variables contributing to the development of DFUs (2.95, 1.45–6.44). Conclusions: SED-time is an independent predictor of the risk of DFU in people with DPN. The monitoring of SED-time with strategies aimed at reducing it should be included in the standard care of diabetic patients.

Sedentary behaviour is an independent predictor of diabetic foot ulcer development: An 8-year prospective study / Orlando, G.; Reeves, N. D.; Boulton, A. J. M.; Ireland, A.; Federici, G.; Federici, A.; Haxhi, J.; Pugliese, G.; Balducci, S.. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - 177:May 29(2021), pp. 1-8. [10.1016/j.diabres.2021.108877]

Sedentary behaviour is an independent predictor of diabetic foot ulcer development: An 8-year prospective study

Haxhi J.;Pugliese G.;
2021

Abstract

Aims: To prospectively explore the association between sedentary time (SED-time) and the development of diabetic foot ulcer (DFU) in people with diabetic peripheral neuropathy (DPN). Methods: 175 DPN individuals who attended the annual evaluation for the SAMBA Study (2012–2019) were included. Main outcome measure was the first diagnosis of DFU. SED-time was measured by the PAS 2.1 questionnaire. Nerve function was evaluated by nerve conduction studies. Vascular function was assessed by Ankle-brachial index (ABI) and pedal pulses. Foot deformity and skin dryness were examined by visual inspection. Results: 62 participants (35.5%) developed a DFU during the study. SED-time was significantly higher in people who developed DFUs (12.8 ± 3.0 vs 9.4 ± 3.1 h/day). Logistic regression showed that among several nervous (motor amplitude, OR 0.33, 95% CI, 0.18–0.60; sensory amplitude, 0.85, 0.77–0.94) and vascular parameters (ABI, 0.23, 0.1–0.61; pedal pulses, 2.81, 0.12–0.63) and foot characteristics (deformity, 2.63, 1.30–5.32; skin dryness, 2.04, 0.95–4.37), SED-time was one of the strongest variables contributing to the development of DFUs (2.95, 1.45–6.44). Conclusions: SED-time is an independent predictor of the risk of DFU in people with DPN. The monitoring of SED-time with strategies aimed at reducing it should be included in the standard care of diabetic patients.
2021
diabetic foot ulcer; diabetic peripheral neuropathy; physical activity; sedentary lifestyle
01 Pubblicazione su rivista::01a Articolo in rivista
Sedentary behaviour is an independent predictor of diabetic foot ulcer development: An 8-year prospective study / Orlando, G.; Reeves, N. D.; Boulton, A. J. M.; Ireland, A.; Federici, G.; Federici, A.; Haxhi, J.; Pugliese, G.; Balducci, S.. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - 177:May 29(2021), pp. 1-8. [10.1016/j.diabres.2021.108877]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1557604
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