Evidence of poor sleep quality in inflammatory bowel disease (IBD, i.e., Crohn's disease and ulcerative colitis) has been reported but never systematically reviewed or meta-analysed. We conducted a sys- tematic review and meta-analysis of pairwise comparisons that included 1) IBD patients/controls, 2) Crohn's disease/ulcerative colitis, 3) active/inactive IBD on standardised measures of sleep quality. PubMed, Medline, PsycINFO, Scopus, and CINAHL were searched up to March 2021. Forty-two studies met the inclusion criteria. Results showed poorer subjective sleep quality in IBD patients than in controls, with moderate effect sizes (g 1⁄4 .49, [95% CI 1⁄4 .32 - .66], p < .001). No differences within IBD subtypes were found (g 1⁄4 .07, [95% CI 1⁄4 .17e.05], p 1⁄4 .208). Individuals with an active IBD reported poorer sleep quality than those in remission, with a large effect size (g 1⁄4 .66, [95% CI 1⁄4 .35 - .98], p < .001). Results on objectively recorded sleep were mixed, with no clear evidence of objective sleep impairments in individuals with IBD. Results support the view of subjective poor sleep quality as a relevant comor- bidity in IBD. As a potential factor affecting immune and inflammatory responses as well as patients' quality of life, sleep quality should be taken into account in the treatment of IBD.

A meta-analysis on sleep quality in inflammatory bowel disease / Ballesio, Andrea; Zagaria, Andrea; Baccini, Flavia; Micheli, Federica; DI NARDO, Giovanni; Lombardo, Caterina. - In: SLEEP MEDICINE REVIEWS. - ISSN 1087-0792. - 60:Jun 17(2021), pp. 1-12. [10.1016/j.smrv.2021.101518]

A meta-analysis on sleep quality in inflammatory bowel disease

Andrea Ballesio
;
Andrea Zagaria;Flavia Baccini;Federica Micheli;Giovanni Di Nardo;Caterina Lombardo
2021

Abstract

Evidence of poor sleep quality in inflammatory bowel disease (IBD, i.e., Crohn's disease and ulcerative colitis) has been reported but never systematically reviewed or meta-analysed. We conducted a sys- tematic review and meta-analysis of pairwise comparisons that included 1) IBD patients/controls, 2) Crohn's disease/ulcerative colitis, 3) active/inactive IBD on standardised measures of sleep quality. PubMed, Medline, PsycINFO, Scopus, and CINAHL were searched up to March 2021. Forty-two studies met the inclusion criteria. Results showed poorer subjective sleep quality in IBD patients than in controls, with moderate effect sizes (g 1⁄4 .49, [95% CI 1⁄4 .32 - .66], p < .001). No differences within IBD subtypes were found (g 1⁄4 .07, [95% CI 1⁄4 .17e.05], p 1⁄4 .208). Individuals with an active IBD reported poorer sleep quality than those in remission, with a large effect size (g 1⁄4 .66, [95% CI 1⁄4 .35 - .98], p < .001). Results on objectively recorded sleep were mixed, with no clear evidence of objective sleep impairments in individuals with IBD. Results support the view of subjective poor sleep quality as a relevant comor- bidity in IBD. As a potential factor affecting immune and inflammatory responses as well as patients' quality of life, sleep quality should be taken into account in the treatment of IBD.
sleep; inflammatory bowel disease; crohn's disease; ulcerative colitis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
A meta-analysis on sleep quality in inflammatory bowel disease / Ballesio, Andrea; Zagaria, Andrea; Baccini, Flavia; Micheli, Federica; DI NARDO, Giovanni; Lombardo, Caterina. - In: SLEEP MEDICINE REVIEWS. - ISSN 1087-0792. - 60:Jun 17(2021), pp. 1-12. [10.1016/j.smrv.2021.101518]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1556934
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