Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.
Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia / Del Casale, A; Rossi-Espagnet, M C; Napolitano, A; Lucignani, M; Bonanni, L; Kotzalidis, G D; Buscajoni, A; Manelfi, L; Perrone, V; Gualtieri, I; Brugnoli, R; De Pisa, E; Girardi, P; Romano, A; Ferracuti, S; Bozzao, A; Pompili, M. - In: ARCHIVES ITALIENNES DE BIOLOGIE. - ISSN 0003-9829. - 159:1(2021), p. 3-20. [10.12871/00039829202111]
Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia
Del Casale, A
;Rossi-Espagnet, M C;Kotzalidis, G D;Buscajoni, A;Gualtieri, I;Brugnoli, R;Girardi, P;Romano, A;Ferracuti, S;Bozzao, A;Pompili, M
2021
Abstract
Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.File | Dimensione | Formato | |
---|---|---|---|
Del Casale_Cerebral cortical thickness_2021.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.35 MB
Formato
Adobe PDF
|
1.35 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.