Background and Objectives: Twenty percent of the patients affected with stage IV antropyloric stomach cancer are hospitalized with a gastric outlet obstruction syndrome (GOOS) requiring its resolution to improve the quality of life (QoL).We present our preliminary short- and mid-term results regarding the influence of endoscopic placement of self-expandable metal stent (SEMS) or open stomach-partitioning gastrojejunostomy in QoL. Materials and Methods: In this prospective randomized longitudinal cohort trial, we randomly assigned 27 patients affected with stage IV antropyloric stomach cancer into two groups: Group 1 (13 patients) who underwent SEMS positioning and Group 2 (14 patients) in whom open stomach-partitioning gastrojejunostomy was performed. The Karnofsky performance scale and QoL assessment using the EQ-5D-5L™ questionnaire was administered before treatment and thereafter at 1, 3, and 6 months. Results: At 1-month, index values showed a statistically significant deterioration of the QoL in patients of Group 2 when compared to those of Group 1 (p = 0.004; CI: 0.04 to 0.21). No differences among the groups were recorded at 3-month; whereas, at 6-month, the index values showed a statistically significant deterioration of the QoL in patients of Group 1 (p = 0.009; CI: -0.25 to -0.043). Conclusions: Early QoL of patients affected with stage IV antropyloric cancer and symptoms of GOOS is significantly better in patients treated with SEMS positioning but at 6-month the QoL significantly decrease in this group of patients. We explained the reasons of this fluctuation with the higher risk of re-hospital admission in the SEMS group.

Palliative surgery or metallic stent positioning for advanced gastric cancer: differences in QOL / Fiori, E.; Crocetti, D.; Sapienza, P.; Cirocchi, R.; Sterpetti, A. V.; Miccini, M.; Accordino, M.; Costi, S.; Lapolla, P.; Mingoli, A.; De Toma, G.; Lamazza, A.. - In: MEDICINA. - ISSN 1010-660X. - 57:5(2021), p. 428. [10.3390/medicina57050428]

Palliative surgery or metallic stent positioning for advanced gastric cancer: differences in QOL

Fiori E.;Crocetti D.;Sapienza P.;Sterpetti A. V.;Miccini M.;Accordino M.;Lapolla P.;Mingoli A.;De Toma G.;Lamazza A.
2021

Abstract

Background and Objectives: Twenty percent of the patients affected with stage IV antropyloric stomach cancer are hospitalized with a gastric outlet obstruction syndrome (GOOS) requiring its resolution to improve the quality of life (QoL).We present our preliminary short- and mid-term results regarding the influence of endoscopic placement of self-expandable metal stent (SEMS) or open stomach-partitioning gastrojejunostomy in QoL. Materials and Methods: In this prospective randomized longitudinal cohort trial, we randomly assigned 27 patients affected with stage IV antropyloric stomach cancer into two groups: Group 1 (13 patients) who underwent SEMS positioning and Group 2 (14 patients) in whom open stomach-partitioning gastrojejunostomy was performed. The Karnofsky performance scale and QoL assessment using the EQ-5D-5L™ questionnaire was administered before treatment and thereafter at 1, 3, and 6 months. Results: At 1-month, index values showed a statistically significant deterioration of the QoL in patients of Group 2 when compared to those of Group 1 (p = 0.004; CI: 0.04 to 0.21). No differences among the groups were recorded at 3-month; whereas, at 6-month, the index values showed a statistically significant deterioration of the QoL in patients of Group 1 (p = 0.009; CI: -0.25 to -0.043). Conclusions: Early QoL of patients affected with stage IV antropyloric cancer and symptoms of GOOS is significantly better in patients treated with SEMS positioning but at 6-month the QoL significantly decrease in this group of patients. We explained the reasons of this fluctuation with the higher risk of re-hospital admission in the SEMS group.
2021
Gastric cancer; stent positioning; stomach-partitioning gastrojejunostomy; humans; palliative care; prospective studies; quality of life; retrospective studies; stents; treatment outcome; stomach neoplasms
01 Pubblicazione su rivista::01a Articolo in rivista
Palliative surgery or metallic stent positioning for advanced gastric cancer: differences in QOL / Fiori, E.; Crocetti, D.; Sapienza, P.; Cirocchi, R.; Sterpetti, A. V.; Miccini, M.; Accordino, M.; Costi, S.; Lapolla, P.; Mingoli, A.; De Toma, G.; Lamazza, A.. - In: MEDICINA. - ISSN 1010-660X. - 57:5(2021), p. 428. [10.3390/medicina57050428]
File allegati a questo prodotto
File Dimensione Formato  
Fiori_Palliative-surgery_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.03 MB
Formato Adobe PDF
1.03 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1552340
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact