The programmable assembly of DNA strands is a promising tool for building tailored bottom-up nanostructures. Here, we present a plasmonic nanosystem obtained by the base-pairing mediated aggregation of gold nanoparticles (NPs) which are separately functionalized with two different single-stranded DNA chains. Their controlled assembly is mediated by a complementary DNA “bridge” sequence. We monitor the formation of DNA assembled NP aggregates in solution, and we study their Surface Enhanced Raman Scattering (SERS) response by comparison with the single NP constituents. We interpret the revealed SERS signatures in terms of the molecular and NP organization at the nanoscale, demonstrating that the action of the DNA bridge molecule yields regular NP aggregates with controlled interparticle distance and reproducible SERS response. In perspective, this demonstrates the potential of the present system as a stable, biocompatible, and recyclable SERS sensor.

DNA-functionalized gold nanoparticle assemblies for Surface Enhanced Raman Scattering / Caprara, D.; Ripanti, F.; Capocefalo, A.; Sarra, A.; Brasili, F.; Petrillo, C.; Fasolato, C.; Postorino, P.. - In: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS. - ISSN 0927-7757. - 589:(2020). [10.1016/j.colsurfa.2019.124399]

DNA-functionalized gold nanoparticle assemblies for Surface Enhanced Raman Scattering

Caprara D.;Ripanti F.
;
Capocefalo A.;Brasili F.;Fasolato C.
;
Postorino P.
2020

Abstract

The programmable assembly of DNA strands is a promising tool for building tailored bottom-up nanostructures. Here, we present a plasmonic nanosystem obtained by the base-pairing mediated aggregation of gold nanoparticles (NPs) which are separately functionalized with two different single-stranded DNA chains. Their controlled assembly is mediated by a complementary DNA “bridge” sequence. We monitor the formation of DNA assembled NP aggregates in solution, and we study their Surface Enhanced Raman Scattering (SERS) response by comparison with the single NP constituents. We interpret the revealed SERS signatures in terms of the molecular and NP organization at the nanoscale, demonstrating that the action of the DNA bridge molecule yields regular NP aggregates with controlled interparticle distance and reproducible SERS response. In perspective, this demonstrates the potential of the present system as a stable, biocompatible, and recyclable SERS sensor.
DNA hybridization; nanoparticle; self-assembly; SERS sensor
01 Pubblicazione su rivista::01a Articolo in rivista
DNA-functionalized gold nanoparticle assemblies for Surface Enhanced Raman Scattering / Caprara, D.; Ripanti, F.; Capocefalo, A.; Sarra, A.; Brasili, F.; Petrillo, C.; Fasolato, C.; Postorino, P.. - In: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS. - ISSN 0927-7757. - 589:(2020). [10.1016/j.colsurfa.2019.124399]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1548890
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