Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

Step economy in the stereoselective synthesis of functionalized oxindoles via organocatalytic domino/one-pot reactions / Bortolami, Martina; Leonelli, Francesca; Feroci, Marta; Vetica, Fabrizio. - In: CURRENT ORGANIC CHEMISTRY. - ISSN 1385-2728. - 25:11(2021), pp. 1321-1344. [10.2174/1385272825666210518124845]

Step economy in the stereoselective synthesis of functionalized oxindoles via organocatalytic domino/one-pot reactions

Bortolami, Martina;Leonelli, Francesca;Feroci, Marta;Vetica, Fabrizio
2021

Abstract

Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.
2021
oxindoles; organocatalysis; domino reactions; one-pot reactions; cascade reactions; asymmetric synthesis; chiral building blocks; bioactive compounds
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Step economy in the stereoselective synthesis of functionalized oxindoles via organocatalytic domino/one-pot reactions / Bortolami, Martina; Leonelli, Francesca; Feroci, Marta; Vetica, Fabrizio. - In: CURRENT ORGANIC CHEMISTRY. - ISSN 1385-2728. - 25:11(2021), pp. 1321-1344. [10.2174/1385272825666210518124845]
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Note: DOI: 10.2174/1385272825666210518124845
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1548709
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