Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the regulation of the DNA methylation pattern involves the poly(ADP-ribosyl)ation (PARylation) process, a post-translational modification of proteins catalysed by the poly(ADP-ribose) polymerase (PARP) enzymes. Experimental data showed that the hyperactivation of PARylation is associated with impaired glucose metabolism and the development of T2DM. Aims of this case-control study were to investigate the association between PARylation and global and site-specific DNA methylation in T2DM and to evaluate metabolic correlates.

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus / Zampieri, Michele; Bacalini, Maria Giulia; Barchetta, Ilaria; Scalea, Stefania; Cimini, Flavia Agata; Bertoccini, Laura; Tagliatesta, Stefano; De Matteis, Giovanna; Zardo, Giuseppe; Cavallo, Maria Gisella; Reale, Anna. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - 13:1(2021). [10.1186/s13148-021-01099-1]

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus

Zampieri, Michele
Primo
;
Bacalini, Maria Giulia;Barchetta, Ilaria;Scalea, Stefania;Cimini, Flavia Agata;Bertoccini, Laura;Tagliatesta, Stefano;De Matteis, Giovanna;Zardo, Giuseppe;Cavallo, Maria Gisella
;
Reale, Anna
Ultimo
2021

Abstract

Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the regulation of the DNA methylation pattern involves the poly(ADP-ribosyl)ation (PARylation) process, a post-translational modification of proteins catalysed by the poly(ADP-ribose) polymerase (PARP) enzymes. Experimental data showed that the hyperactivation of PARylation is associated with impaired glucose metabolism and the development of T2DM. Aims of this case-control study were to investigate the association between PARylation and global and site-specific DNA methylation in T2DM and to evaluate metabolic correlates.
2021
5-Hydroxymethylcytosine; DNA methylation; epigenetics; PARylation; type 2 diabetes mellitus
01 Pubblicazione su rivista::01a Articolo in rivista
Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus / Zampieri, Michele; Bacalini, Maria Giulia; Barchetta, Ilaria; Scalea, Stefania; Cimini, Flavia Agata; Bertoccini, Laura; Tagliatesta, Stefano; De Matteis, Giovanna; Zardo, Giuseppe; Cavallo, Maria Gisella; Reale, Anna. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - 13:1(2021). [10.1186/s13148-021-01099-1]
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Note: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01099-1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1548597
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