Radiation therapy is currently the most utilized technique for the treatment of tumors by means ofionizing radiation, such as electrons, protons and x/gamma rays, depending on the type, size and depth ofthe cancer mass. Radiation therapy has in general fulfilled the main requirement of targeting thus damagingthe malignant cells and sparing the healthy tissues as best as possible. In this scenario, electron linearaccelerators have been operated as viable tools for the delivery of both high-energetic electrons and x-raybeams, which are obtained via the bremsstrahlung process of the electrons hitting on a high-Z material.Recently, it has been experimentally demonstrated that ultrahigh dose-rate bursts of electrons and x-raybeams increase the differential response between healthy and tumor tissues. This beneficial response isreferred to as the FLASH effect. For this purpose, we have developed the first dedicated compactS-bandlinear accelerator for FLASH radiotherapy. This linac is optimized for a nominal energy of 7 MeV and apulsed electron beam current of 100 mA and above. The accelerator is mounted on a remote-controlledsystem for preclinical research studies in the FLASH regime. We will show the rf and beam dynamicsdesign of theS-band linac as well as the commissioning and high-power rf tests. Furthermore, the results ofthe dosimetric measurements will be illustrated

Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy / Faillace, L.; Barone, S.; Battistoni, G.; Di Francesco, M.; Felici, G.; Ficcadenti, L.; Franciosini, G.; Galante, F.; Giuliano, L.; Grasso, L.; Mostacci, A.; Muraro, S.; Pacitti, M.; Palumbo, L.; Patera, V.; Migliorati, M.. - In: PHYSICAL REVIEW. ACCELERATORS AND BEAMS. - ISSN 2469-9888. - 24:5(2021). [10.1103/PhysRevAccelBeams.24.050102]

Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

Faillace, L.;Ficcadenti, L.;Franciosini, G.;Galante, F.;Giuliano, L.;Mostacci, A.;Pacitti, M.;Palumbo, L.;Patera, V.;Migliorati, M.
2021

Abstract

Radiation therapy is currently the most utilized technique for the treatment of tumors by means ofionizing radiation, such as electrons, protons and x/gamma rays, depending on the type, size and depth ofthe cancer mass. Radiation therapy has in general fulfilled the main requirement of targeting thus damagingthe malignant cells and sparing the healthy tissues as best as possible. In this scenario, electron linearaccelerators have been operated as viable tools for the delivery of both high-energetic electrons and x-raybeams, which are obtained via the bremsstrahlung process of the electrons hitting on a high-Z material.Recently, it has been experimentally demonstrated that ultrahigh dose-rate bursts of electrons and x-raybeams increase the differential response between healthy and tumor tissues. This beneficial response isreferred to as the FLASH effect. For this purpose, we have developed the first dedicated compactS-bandlinear accelerator for FLASH radiotherapy. This linac is optimized for a nominal energy of 7 MeV and apulsed electron beam current of 100 mA and above. The accelerator is mounted on a remote-controlledsystem for preclinical research studies in the FLASH regime. We will show the rf and beam dynamicsdesign of theS-band linac as well as the commissioning and high-power rf tests. Furthermore, the results ofthe dosimetric measurements will be illustrated
2021
Beam diagnostics; Radio frequency calculations; Room temperature RF
01 Pubblicazione su rivista::01a Articolo in rivista
Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy / Faillace, L.; Barone, S.; Battistoni, G.; Di Francesco, M.; Felici, G.; Ficcadenti, L.; Franciosini, G.; Galante, F.; Giuliano, L.; Grasso, L.; Mostacci, A.; Muraro, S.; Pacitti, M.; Palumbo, L.; Patera, V.; Migliorati, M.. - In: PHYSICAL REVIEW. ACCELERATORS AND BEAMS. - ISSN 2469-9888. - 24:5(2021). [10.1103/PhysRevAccelBeams.24.050102]
File allegati a questo prodotto
File Dimensione Formato  
Faillace_compact_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 3.04 MB
Formato Adobe PDF
3.04 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1548061
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 12
social impact