In the early years of the disease recognition, hypertrophic cardiomyopathy (HCM) was viewed as an ominous disease with unfavourable prognosis and with an annual mortality between 4% and 6%. At that time, 73% of the patients reported in the literature came from only two referral centres. With the introduction of echocardiography, our understanding of HCM has improved and non-selected patient populations were assembled in several centres. A more benign prognostic profile was documented with an annual mortality rate of 1.5% or less. In the 2000s, important therapeutic interventions further improved the prognosis of patients with HCM: implantable-cardioverter defibrillator for prevention of sudden death, heart transplantation for treatment of severe refractory heart failure, and an extensive treatment with myectomy for relief of left ventricular outflow tract gradient. The natural history of HCM has changed substantially with contemporary treatment achieving an annual mortality rate less than 1% with extended longevity and a greatly improved quality of life.
The natural history of hypertrophic cardiomyopathy / Autore, C.; Musumeci, M. B.. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1520-765X. - 22:Suppl L(2020), pp. L11-L14.
|Titolo:||The natural history of hypertrophic cardiomyopathy|
AUTORE, Camillo (Corresponding author)
|Data di pubblicazione:||2020|
|Citazione:||The natural history of hypertrophic cardiomyopathy / Autore, C.; Musumeci, M. B.. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1520-765X. - 22:Suppl L(2020), pp. L11-L14.|
|Appartiene alla tipologia:||01a Articolo in rivista|