(1) Background: Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) emerged in Wuhan, China, in late 2019. The development of effective and safe vaccines against SARS-CoV-2 has been extremely fast. The list of orofacial adverse effects of BNT162b2 and mRNA-1273 vaccines based on the clinical trials are reported to be rare. The aim of this study was to investigate the facial and oral manifestations of COVID-19 vaccination using a survey-based study. (2) Methods: The questionnaire was developed using Google Forms and sent anonymously to a total of 700 subjects (medical personnel) in Poland, Italy, and other EU countries. (3) Results: 223 people answered the questionnaire, mainly vaccinated with BNT162b2. Only 3.1% and 5.4% experienced oral and facial symptoms, respectively. General diseases presence and age have significant influence on the probabil- ity of oral symptoms occurrence after the second dose. Facial symptoms are correlated with general disease; autoimmune pathologies and age, at first and second dose, respectively. Gender, smoking and regular medication intake have significant influence on the probability of taking an absence day. Gender, age, and smoking have a significant influence on the duration of symptoms after second dose. (4) Conclusions: Based on the results of this preliminary survey, there is no observed significant correlation between vaccine administration for COVID-19 and facial and oral manifestations.

Facial and oral manifestations following COVID-19 vaccination: a survey-based study and a first perspective / Mazur, Marta; Duś-Ilnicka, Irena; Jedliński, Maciej; Ndokaj, Artnora; Janiszewska-Olszowska, Joanna; Ardan, Roman; Radwan-Oczko, Malgorzata; Guerra, Fabrizio; Luzzi, Valeria; Vozza, Iole; Marasca, Roberto; Ottolenghi, Livia; Polimeni, Antonella. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:9(2021). [10.3390/ijerph18094965]

Facial and oral manifestations following COVID-19 vaccination: a survey-based study and a first perspective

Mazur, Marta
Primo
;
Ndokaj, Artnora;Guerra, Fabrizio;Luzzi, Valeria;Vozza, Iole;Ottolenghi, Livia
Penultimo
;
Polimeni, Antonella
Ultimo
2021

Abstract

(1) Background: Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) emerged in Wuhan, China, in late 2019. The development of effective and safe vaccines against SARS-CoV-2 has been extremely fast. The list of orofacial adverse effects of BNT162b2 and mRNA-1273 vaccines based on the clinical trials are reported to be rare. The aim of this study was to investigate the facial and oral manifestations of COVID-19 vaccination using a survey-based study. (2) Methods: The questionnaire was developed using Google Forms and sent anonymously to a total of 700 subjects (medical personnel) in Poland, Italy, and other EU countries. (3) Results: 223 people answered the questionnaire, mainly vaccinated with BNT162b2. Only 3.1% and 5.4% experienced oral and facial symptoms, respectively. General diseases presence and age have significant influence on the probabil- ity of oral symptoms occurrence after the second dose. Facial symptoms are correlated with general disease; autoimmune pathologies and age, at first and second dose, respectively. Gender, smoking and regular medication intake have significant influence on the probability of taking an absence day. Gender, age, and smoking have a significant influence on the duration of symptoms after second dose. (4) Conclusions: Based on the results of this preliminary survey, there is no observed significant correlation between vaccine administration for COVID-19 and facial and oral manifestations.
2021
COVID-19; COVID-19 vaccines; vaccines; BNT162b2; mRNA-1273; survey; questionnaire; oral signs; facial signs; orofacial manifestations
01 Pubblicazione su rivista::01a Articolo in rivista
Facial and oral manifestations following COVID-19 vaccination: a survey-based study and a first perspective / Mazur, Marta; Duś-Ilnicka, Irena; Jedliński, Maciej; Ndokaj, Artnora; Janiszewska-Olszowska, Joanna; Ardan, Roman; Radwan-Oczko, Malgorzata; Guerra, Fabrizio; Luzzi, Valeria; Vozza, Iole; Marasca, Roberto; Ottolenghi, Livia; Polimeni, Antonella. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:9(2021). [10.3390/ijerph18094965]
File allegati a questo prodotto
File Dimensione Formato  
Mazur_Facial and Oral_2021.pdf

accesso aperto

Note: https://www.mdpi.com/1660-4601/18/9/4965
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 916.96 kB
Formato Adobe PDF
916.96 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1547691
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 27
social impact