Objective: The aim was to identify predictors of adequate pre-operative sizing and planning for chimney endovascular aortic repair (ChEVAR) in order to reduce the incidence of persistent type Ia endoleaks (IaELs) without influencing chimney graft (CG) patency. Methods: Consecutive patients who underwent ChEVAR between January 2009 and December 2017 at a single centre were evaluated retrospectively. Included were patients treated with one device combination (Medtronic Endurant mated with Getinge Advanta V12/iCast) and placement of single or double CG. The freedom from IaEL related re-interventions and primary CG patency was estimated by measuring aortic stent graft oversizing (OS), total neck length (TNL), and a composite parameter (L-OS: TNL [mm] + OS [%]). Results: Seventy-three patients who underwent placement of 101 CGs (45 single, 28 double) met the inclusion criteria. The median radiological follow up was 25.5 (interquartile range [IQR] 12–48) months. Freedom from IaEL related re-intervention was achieved in 94.6% with a median OS of 38.5% (IQR 30%–44%, p = .004), TNL 19 mm (16–25 mm, p = .62), and L-OS 59 (51–65, p = .018). Primary CG patency was achieved in 95% of the cases with a median OS of 36% (29%–42%, p = .008), TNL 19 mm (15.5–26 mm, p = .91), and L-OS 57 (50–64, p = .005). By using the receiver operating characteristic curve, an optimal cut off to prevent IaEL related re-interventions was identified by an OS of 30% (p < .001; L-OS 55, p = .006) and to avoid CG stenosis/occlusions by OS 42% (p < .001; L-OS 65, p < .001). In multivariable analysis, aortic endograft OS was the only independent parameter preventive for IaEL related re-intervention (odds ratio, 0.78; 95% confidence interval, 0.61–0.99). Conclusion: With the Endurant-Advanta V12/iCast combination, an aortic stent graft OS of at least 30% (range 30%–42%) should be used to avoid type Ia endoleaks and likewise to ensure CG patency.

The PROTAGORAS 2.0 study to identify sizing and planning predictors for optimal outcomes in abdominal chimney endovascular procedures / Fazzini, S.; Martinelli, O.; Torsello, G.; Austermann, M.; Pipitone, M. D.; Torsello, G. F.; Irace, L.; Donas, K. P.. - In: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. - ISSN 1078-5884. - 61:4(2021), pp. 591-602. [10.1016/j.ejvs.2020.11.019]

The PROTAGORAS 2.0 study to identify sizing and planning predictors for optimal outcomes in abdominal chimney endovascular procedures

Fazzini S.;Martinelli O.;
2021

Abstract

Objective: The aim was to identify predictors of adequate pre-operative sizing and planning for chimney endovascular aortic repair (ChEVAR) in order to reduce the incidence of persistent type Ia endoleaks (IaELs) without influencing chimney graft (CG) patency. Methods: Consecutive patients who underwent ChEVAR between January 2009 and December 2017 at a single centre were evaluated retrospectively. Included were patients treated with one device combination (Medtronic Endurant mated with Getinge Advanta V12/iCast) and placement of single or double CG. The freedom from IaEL related re-interventions and primary CG patency was estimated by measuring aortic stent graft oversizing (OS), total neck length (TNL), and a composite parameter (L-OS: TNL [mm] + OS [%]). Results: Seventy-three patients who underwent placement of 101 CGs (45 single, 28 double) met the inclusion criteria. The median radiological follow up was 25.5 (interquartile range [IQR] 12–48) months. Freedom from IaEL related re-intervention was achieved in 94.6% with a median OS of 38.5% (IQR 30%–44%, p = .004), TNL 19 mm (16–25 mm, p = .62), and L-OS 59 (51–65, p = .018). Primary CG patency was achieved in 95% of the cases with a median OS of 36% (29%–42%, p = .008), TNL 19 mm (15.5–26 mm, p = .91), and L-OS 57 (50–64, p = .005). By using the receiver operating characteristic curve, an optimal cut off to prevent IaEL related re-interventions was identified by an OS of 30% (p < .001; L-OS 55, p = .006) and to avoid CG stenosis/occlusions by OS 42% (p < .001; L-OS 65, p < .001). In multivariable analysis, aortic endograft OS was the only independent parameter preventive for IaEL related re-intervention (odds ratio, 0.78; 95% confidence interval, 0.61–0.99). Conclusion: With the Endurant-Advanta V12/iCast combination, an aortic stent graft OS of at least 30% (range 30%–42%) should be used to avoid type Ia endoleaks and likewise to ensure CG patency.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1547685
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