Introduction. Living donation in adult liver transplantation (LDLTx) is an important resource because of the waiting list growth. We started a living donor program to overcome the shortage of cadaveric sources. Patients. From May 2001 to May 2003, 36 patients underwent LDLTx: 27 received a right lobe, 8 received a left lobe, and 1 received segments II and III. Results. The 1-year actuarial survival rate was 77.7%, with a mean follow-up, in survivors, of 754 ± 248 days. Eleven of 27 (40.7%) right lobe recipients died. Among left graft recipients, 3 patients died (33%). We undertook retransplantation in 4 cases, because of 2 "small for size" syndrome, 1 late hepatic artery thrombosis, and 1 early portal vein thrombosis. After a period of 797 days, all 36 donors returned to a normal social and working life. Two donors, who underwent right lobe donation, experienced major complications: 1 case of biliary stenosis, treated by stenting, and 1 case of biliary leak from the cut surface of the liver, requiring laparotomy and abscess drainage. Left lobe donors developed no complications. Conclusions. LDLTx has a learning curve for experienced liver transplantation surgeons. Our last 18 cases showed better survivals than the first 18 (9 deaths vs 5), even if, in the latter group, we transplanted 8 left livers. In our experience, LDLTx of a left liver graft has an increased risk of "small for size syndrome," but patients, both donors and recipients, report improved outcomes.

Living donor liver transplantation in adult patients. Our experience / Dazzi, A.; Lauro, A.; Di Benedetto, F.; Masetti, M.; Cautero, N.; De Ruvo, N.; Quintini, C.; Ramacciato, G.; Miller, C. M.; Pinna, A. D.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 37:6(2005), pp. 2595-2596. [10.1016/j.transproceed.2005.06.061]

Living donor liver transplantation in adult patients. Our experience

Lauro A.
Secondo
Writing – Review & Editing
;
Ramacciato G.;
2005

Abstract

Introduction. Living donation in adult liver transplantation (LDLTx) is an important resource because of the waiting list growth. We started a living donor program to overcome the shortage of cadaveric sources. Patients. From May 2001 to May 2003, 36 patients underwent LDLTx: 27 received a right lobe, 8 received a left lobe, and 1 received segments II and III. Results. The 1-year actuarial survival rate was 77.7%, with a mean follow-up, in survivors, of 754 ± 248 days. Eleven of 27 (40.7%) right lobe recipients died. Among left graft recipients, 3 patients died (33%). We undertook retransplantation in 4 cases, because of 2 "small for size" syndrome, 1 late hepatic artery thrombosis, and 1 early portal vein thrombosis. After a period of 797 days, all 36 donors returned to a normal social and working life. Two donors, who underwent right lobe donation, experienced major complications: 1 case of biliary stenosis, treated by stenting, and 1 case of biliary leak from the cut surface of the liver, requiring laparotomy and abscess drainage. Left lobe donors developed no complications. Conclusions. LDLTx has a learning curve for experienced liver transplantation surgeons. Our last 18 cases showed better survivals than the first 18 (9 deaths vs 5), even if, in the latter group, we transplanted 8 left livers. In our experience, LDLTx of a left liver graft has an increased risk of "small for size syndrome," but patients, both donors and recipients, report improved outcomes.
2005
actuarial analysis; adult; aged; female; hepatectomy; humans; liver transplantation; male; middle aged; postoperative complications; reoperation; retrospective studies; survival analysis; tissue and organ harvesting; living donors
01 Pubblicazione su rivista::01l Trial clinico
Living donor liver transplantation in adult patients. Our experience / Dazzi, A.; Lauro, A.; Di Benedetto, F.; Masetti, M.; Cautero, N.; De Ruvo, N.; Quintini, C.; Ramacciato, G.; Miller, C. M.; Pinna, A. D.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 37:6(2005), pp. 2595-2596. [10.1016/j.transproceed.2005.06.061]
File allegati a questo prodotto
File Dimensione Formato  
Dazzi_Living-Donor-Liver_2005.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 49.1 kB
Formato Adobe PDF
49.1 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1547432
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact