Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1) provide an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.

Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques / Petracca, M; Margoni, M; Bommarito, G; Inglese, M.. - In: NEUROLOGY AND THERAPY. - ISSN 2193-8253. - 7:2(2018), pp. 265-285. [10.1007/s40120-018-0103-2.]

Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques.

Petracca M
Primo
;
2018

Abstract

Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1) provide an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.
2018
advanced imaging; biomarker; clinical trials; progressive multiple sclerosis.
01 Pubblicazione su rivista::01a Articolo in rivista
Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques / Petracca, M; Margoni, M; Bommarito, G; Inglese, M.. - In: NEUROLOGY AND THERAPY. - ISSN 2193-8253. - 7:2(2018), pp. 265-285. [10.1007/s40120-018-0103-2.]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1544557
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