For the 8–29% colorectal cancers that initially manifest with obstruction, emergency surgery (ES) was traditionally considered the only available therapy, despite high morbidity and mortality rates and the need for colostomy creation. More recently, malignant obstruction of the left colon can be temporized by endoscopic placement of a self-expanding metallic stent (SEMS), used as bridge to surgery (BTS), facilitating a laparoscopic approach and increasing the likelihood that a primary anastomosis instead of stoma would be used. Despite these attractive outcomes, the superiority of the BTS approach is not clearly established. Few authors have stressed the potential cancer risk associated with perforations that may occur during endoscopic stent placement, facilitating neoplastic spread and negatively impacting prognosis. For this reason, the current literature focuses on long-term oncologic outcomes such as disease-free survival, overall survival and recurrence rate that do seem not to differ between the ES and BTS approaches. This lack of consensus has spawned differing and sometimes discordant guidelines worldwide. In conclusion, 20 years after the first description of a colonic stent as BTS, the debate is still open, but the growing number of articles about the use of SEMS as a BTS signifies a great interest in the topic. We hope that these data will finally converge on a single set of recommendations supporting a management strategy with well-demonstrated superiority.

Obstructing left-sided colonic cancer. Is endoscopic stenting a bridge to surgery or a bridge to nowhere? / Lauro, A.; Binetti, M.; Vaccari, S.; Cervellera, M.; Tonini, V.. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - 65:10(2020), pp. 2789-2799. [10.1007/s10620-020-06403-2]

Obstructing left-sided colonic cancer. Is endoscopic stenting a bridge to surgery or a bridge to nowhere?

Lauro A.
Primo
Writing – Review & Editing
;
Vaccari S.
;
2020

Abstract

For the 8–29% colorectal cancers that initially manifest with obstruction, emergency surgery (ES) was traditionally considered the only available therapy, despite high morbidity and mortality rates and the need for colostomy creation. More recently, malignant obstruction of the left colon can be temporized by endoscopic placement of a self-expanding metallic stent (SEMS), used as bridge to surgery (BTS), facilitating a laparoscopic approach and increasing the likelihood that a primary anastomosis instead of stoma would be used. Despite these attractive outcomes, the superiority of the BTS approach is not clearly established. Few authors have stressed the potential cancer risk associated with perforations that may occur during endoscopic stent placement, facilitating neoplastic spread and negatively impacting prognosis. For this reason, the current literature focuses on long-term oncologic outcomes such as disease-free survival, overall survival and recurrence rate that do seem not to differ between the ES and BTS approaches. This lack of consensus has spawned differing and sometimes discordant guidelines worldwide. In conclusion, 20 years after the first description of a colonic stent as BTS, the debate is still open, but the growing number of articles about the use of SEMS as a BTS signifies a great interest in the topic. We hope that these data will finally converge on a single set of recommendations supporting a management strategy with well-demonstrated superiority.
2020
Colorectal cancer; Emergency surgery; International guidelines; Left-sided obstruction; Long-term outcomes; SEMS; Short-term outcomes; “Bridge to Surgery”; Colonoscopy; Colorectal Neoplasms; Humans; Intestinal Obstruction; Patient Safety; Risk Assessment; Risk Factors; Treatment Outcome; Self Expandable Metallic Stents
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Obstructing left-sided colonic cancer. Is endoscopic stenting a bridge to surgery or a bridge to nowhere? / Lauro, A.; Binetti, M.; Vaccari, S.; Cervellera, M.; Tonini, V.. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - 65:10(2020), pp. 2789-2799. [10.1007/s10620-020-06403-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1544067
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