Objective: Given the therapeutic and non-therapeutic use of the tadalafil, (phosphodiesterase-5 inhibitor, PDE-5i), we examined its effects on anaerobic performance indices. Methods: In total, 12 well-trained subjects reported to the laboratory on two occasions 1 week apart to perform a 30 s Wingate anaerobic power test (WAnT) on a bicycle ergometer. The day before the WAnT, the subjects were double-blinded to receive an oral dose of tadalafil (20 mg) or placebo. Blood lactate value at rest and 1, 3, 6 and 10 minutes of recovery phase, mean power, peak power, time to peak power and fatigue index were assessed for each WAnT. Results: Blood lactate values at the 3-min recovery WAnT increased significantly in the tadalafil condition (mean (SD) 13.9 (1.7) v 12.8 (1.3) mmol/l; p<0.05) and time to peak power decreased significantly (6.3 (1.3) v 5.7 (1.5) s; p = 0.05). No differences were observed in any other parameters between the two conditions. Conclusion: The primary finding of this investigation was that the administration of a single dose of a long-term PDE-5i does not substantially influence anaerobic performance indices. However, results demonstrated both an increase in lactate values at the 3-min point of the recovery phase and a decrease in time to peak power.

Effect of tadalafil on anaerobic performance indices in healthy athletes / Guidetti, L.; Emerenziani, G. P.; Gallotta, M. C.; Pigozzi, F.; Di Luigi, L.; Baldari, C.. - In: BRITISH JOURNAL OF SPORTS MEDICINE. - ISSN 0306-3674. - 42:2(2008), pp. 130-133. [10.1136/bjsm.2007.037630]

Effect of tadalafil on anaerobic performance indices in healthy athletes

Emerenziani G. P.;Gallotta M. C.;
2008

Abstract

Objective: Given the therapeutic and non-therapeutic use of the tadalafil, (phosphodiesterase-5 inhibitor, PDE-5i), we examined its effects on anaerobic performance indices. Methods: In total, 12 well-trained subjects reported to the laboratory on two occasions 1 week apart to perform a 30 s Wingate anaerobic power test (WAnT) on a bicycle ergometer. The day before the WAnT, the subjects were double-blinded to receive an oral dose of tadalafil (20 mg) or placebo. Blood lactate value at rest and 1, 3, 6 and 10 minutes of recovery phase, mean power, peak power, time to peak power and fatigue index were assessed for each WAnT. Results: Blood lactate values at the 3-min recovery WAnT increased significantly in the tadalafil condition (mean (SD) 13.9 (1.7) v 12.8 (1.3) mmol/l; p<0.05) and time to peak power decreased significantly (6.3 (1.3) v 5.7 (1.5) s; p = 0.05). No differences were observed in any other parameters between the two conditions. Conclusion: The primary finding of this investigation was that the administration of a single dose of a long-term PDE-5i does not substantially influence anaerobic performance indices. However, results demonstrated both an increase in lactate values at the 3-min point of the recovery phase and a decrease in time to peak power.
2008
Anaerobic Threshold; Athletic Performance; Carbolines; Double-Blind Method; Exercise; Exercise Test; Humans; Lactic Acid; Male; Phosphodiesterase Inhibitors; Tadalafil
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of tadalafil on anaerobic performance indices in healthy athletes / Guidetti, L.; Emerenziani, G. P.; Gallotta, M. C.; Pigozzi, F.; Di Luigi, L.; Baldari, C.. - In: BRITISH JOURNAL OF SPORTS MEDICINE. - ISSN 0306-3674. - 42:2(2008), pp. 130-133. [10.1136/bjsm.2007.037630]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1542673
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