This invention relates to the prepn. of sol. forms of complexes of histone deacetylase inhibitors, such as I (X = CH, N), with cyclodextrins. The prepn. process involved the formation of inclusion complexes with cyclodextrins with the aid of microwaves. The prepd. complexes were claimed for therapeutic use in the treatment of diseases, such as leishmania, diseases related to aging, mental retardation, neurodegeneration, anxiety, osteoarthritis, psychoses, cancer, type I diabetes, epilepsy and spinal muscular atrophy. [on SciFinder(R)]
Preparation of soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins for use in pharmaceutical compositions / Di Rienzo, Barbara; Mai, Antonello.. - (2007).
Preparation of soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins for use in pharmaceutical compositions
Mai, Antonello.
2007
Abstract
This invention relates to the prepn. of sol. forms of complexes of histone deacetylase inhibitors, such as I (X = CH, N), with cyclodextrins. The prepn. process involved the formation of inclusion complexes with cyclodextrins with the aid of microwaves. The prepd. complexes were claimed for therapeutic use in the treatment of diseases, such as leishmania, diseases related to aging, mental retardation, neurodegeneration, anxiety, osteoarthritis, psychoses, cancer, type I diabetes, epilepsy and spinal muscular atrophy. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
