Title compds. [I; R = (cyclo)alkyl; R1 = H or alkyl; R2 = (un)substituted Ph; Z = O or S] were prepd. Thus, I (R = CHMeEt, R1 = H, R2 = C6H4Me-3, Z = O) had EC50 of >347μM for redn. of viability of MT-4 lymphocytes and 0.54μM for protection of MT-4 against HIV-1-induced cytopathogenicity. [on SciFinder(R)]
Preparation of 6-benzyl-4-oxopyrimidines as antiviral agents / Artico, Marino; Massa, Silvio; Mai, Antonello; La Colla, Paolo; Marongiu, Maria Elena; Tramontano, Enzo.. - (1994).
Preparation of 6-benzyl-4-oxopyrimidines as antiviral agents
Artico, Marino;Mai, Antonello;
1994
Abstract
Title compds. [I; R = (cyclo)alkyl; R1 = H or alkyl; R2 = (un)substituted Ph; Z = O or S] were prepd. Thus, I (R = CHMeEt, R1 = H, R2 = C6H4Me-3, Z = O) had EC50 of >347μM for redn. of viability of MT-4 lymphocytes and 0.54μM for protection of MT-4 against HIV-1-induced cytopathogenicity. [on SciFinder(R)]File allegati a questo prodotto
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