Tranylcypromine derivs. useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions assocd. with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compds. belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the prepn. of these compds., as well as to compns. contg. them and to therapeutic use thereof. [on SciFinder(R)]

Tranylcypromine derivatives as inhibitors of histone demethylases lsd1 and/or lsd2 / Minucci, Saverio; Mai, Antonello; Mattevi, Andrea.. - (2010).

Tranylcypromine derivatives as inhibitors of histone demethylases lsd1 and/or lsd2

Mai, Antonello;
2010

Abstract

Tranylcypromine derivs. useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions assocd. with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compds. belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the prepn. of these compds., as well as to compns. contg. them and to therapeutic use thereof. [on SciFinder(R)]
2010
tranylcypromine LSD1 LSD2
05 Brevetto::05a Brevetto
Tranylcypromine derivatives as inhibitors of histone demethylases lsd1 and/or lsd2 / Minucci, Saverio; Mai, Antonello; Mattevi, Andrea.. - (2010).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1541436
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