Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.

Ischemic mitral regurgitation. a multifaceted syndrome with evolving therapies / Vinciguerra, Mattia; Grigioni, Francesco; Romiti, Silvia; Benfari, Giovanni; Rose, David; Spadaccio, Cristiano; Cimino, Sara; De Bellis, Antonio; Greco, Ernesto. - In: BIOMEDICINES. - ISSN 2227-9059. - 9:5(2021). [10.3390/biomedicines9050447]

Ischemic mitral regurgitation. a multifaceted syndrome with evolving therapies

Vinciguerra, Mattia
Primo
Writing – Original Draft Preparation
;
Romiti, Silvia
Data Curation
;
Cimino, Sara
Conceptualization
;
Greco, Ernesto
Ultimo
Writing – Review & Editing
2021

Abstract

Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1541195
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