Type 2 diabetes mellitus (T2DM) is associated with oxidative stress but the underlying mechanisms promoting oxidative stress as well as its relationship with cardiovascular events is still unclear. In 375 T2DM patients who were followed-up for approximately 5 years we measured the serum levels of soluble NOX2–derived peptide (sNOX2-dp), a marker of Nox2 activation, and albumin, a powerful antioxidant protein. In the entire cohort soluble Nox2 and serum albumin were significantly correlated (r = −0.348, P < 0.0001). During the follow-up 49 cardiovascular events (CVE) were registered, of which 45 were non-fatal myocardial infarction (MI); patients with non-fatal MI had significantly higher soluble NOX2/albumin ratio compared to cardiovascular events-free patients. Cox regression analysis showed a significant association between sNox2-dp/serum albumin ratio and the incidental risk of non-fatal MI (HR 1.106, CI95% 1.020–1.198, P = 0.014). The study suggests that redox status imbalance negatively influences vascular outcomes in T2DM.

Nox2 up-regulation and hypoalbuminemia in patients with type 2 diabetes mellitus / Succurro, E.; Andreozzi, F.; Carnevale, R.; Sciacqua, A.; Cammisotto, V.; Cassano, V.; Mannino, G. C.; Fiorentino, T. V.; Pastori, D.; Pignatelli, P.; Sesti, G.; Violi, F.. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 168:(2021), pp. 1-5. [10.1016/j.freeradbiomed.2021.03.026]

Nox2 up-regulation and hypoalbuminemia in patients with type 2 diabetes mellitus

Carnevale R.;Cammisotto V.;Pastori D.;Pignatelli P.;Sesti G.
Penultimo
Writing – Review & Editing
;
Violi F.
2021

Abstract

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress but the underlying mechanisms promoting oxidative stress as well as its relationship with cardiovascular events is still unclear. In 375 T2DM patients who were followed-up for approximately 5 years we measured the serum levels of soluble NOX2–derived peptide (sNOX2-dp), a marker of Nox2 activation, and albumin, a powerful antioxidant protein. In the entire cohort soluble Nox2 and serum albumin were significantly correlated (r = −0.348, P < 0.0001). During the follow-up 49 cardiovascular events (CVE) were registered, of which 45 were non-fatal myocardial infarction (MI); patients with non-fatal MI had significantly higher soluble NOX2/albumin ratio compared to cardiovascular events-free patients. Cox regression analysis showed a significant association between sNox2-dp/serum albumin ratio and the incidental risk of non-fatal MI (HR 1.106, CI95% 1.020–1.198, P = 0.014). The study suggests that redox status imbalance negatively influences vascular outcomes in T2DM.
2021
albumin; cardiovascular events; diabetes; nox2; oxidative stress
01 Pubblicazione su rivista::01a Articolo in rivista
Nox2 up-regulation and hypoalbuminemia in patients with type 2 diabetes mellitus / Succurro, E.; Andreozzi, F.; Carnevale, R.; Sciacqua, A.; Cammisotto, V.; Cassano, V.; Mannino, G. C.; Fiorentino, T. V.; Pastori, D.; Pignatelli, P.; Sesti, G.; Violi, F.. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 168:(2021), pp. 1-5. [10.1016/j.freeradbiomed.2021.03.026]
File allegati a questo prodotto
File Dimensione Formato  
Succurro_Nox2-up_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 398.23 kB
Formato Adobe PDF
398.23 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1540250
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact