Eukaryotic genomes are wrapped around nucleosomes and organized into different levels of chromatin structure. Chromatin organization has a crucial role in regulating all cellular processes involving DNA-protein interactions, such as DNA transcription, replication, recombination and repair. Histone post-translational modifications (HPTMs) have a prominent role in chromatin regulation, acting as a sophisticated molecular code, which is interpreted by HPTM-specific effectors. Here, we review the role of histone lysine methylation changes in regulating the response to radiation-induced genotoxic damage in mammalian cells. We also discuss the role of histone methyltransferases (HMTs) and histone demethylases (HDMs) and the effects of the modulation of their expression and/or the pharmacological inhibition of their activity on the radio-sensitivity of different cell lines. Finally, we provide a bioinformatic analysis of published datasets showing how the mRNA levels of known HMTs and HDMs are modulated in different cell lines by exposure to different irradiation conditions.

The role of histone lysine methylation in the response of mammalian cells to Ionizing radiation / Di Nisio, Elena; Lupo, Giuseppe; Licursi, Valerio; Negri, Rodolfo. - In: FRONTIERS IN GENETICS. - ISSN 1664-8021. - 12:(2021). [10.3389/fgene.2021.639602]

The role of histone lysine methylation in the response of mammalian cells to Ionizing radiation

Di Nisio, Elena
Primo
;
Lupo, Giuseppe
Secondo
;
Licursi, Valerio
;
Negri, Rodolfo
2021

Abstract

Eukaryotic genomes are wrapped around nucleosomes and organized into different levels of chromatin structure. Chromatin organization has a crucial role in regulating all cellular processes involving DNA-protein interactions, such as DNA transcription, replication, recombination and repair. Histone post-translational modifications (HPTMs) have a prominent role in chromatin regulation, acting as a sophisticated molecular code, which is interpreted by HPTM-specific effectors. Here, we review the role of histone lysine methylation changes in regulating the response to radiation-induced genotoxic damage in mammalian cells. We also discuss the role of histone methyltransferases (HMTs) and histone demethylases (HDMs) and the effects of the modulation of their expression and/or the pharmacological inhibition of their activity on the radio-sensitivity of different cell lines. Finally, we provide a bioinformatic analysis of published datasets showing how the mRNA levels of known HMTs and HDMs are modulated in different cell lines by exposure to different irradiation conditions.
2021
DNA damage; DNA repair; HPTMs; histone methylation; ionizing radiation
01 Pubblicazione su rivista::01a Articolo in rivista
The role of histone lysine methylation in the response of mammalian cells to Ionizing radiation / Di Nisio, Elena; Lupo, Giuseppe; Licursi, Valerio; Negri, Rodolfo. - In: FRONTIERS IN GENETICS. - ISSN 1664-8021. - 12:(2021). [10.3389/fgene.2021.639602]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1538086
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