Introduction: SARS-CoV-2 pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.

The importance of genomic analysis in cracking the Coronavirus pandemic / Zella, Davide; Giovanetti, Marta; Cella, Eleonora; Borsetti, Alessandra; Ciotti, Marco; Ceccarelli, Giancarlo; D'Ettorre, Gabriella; Pezzuto, Aldo; Tambone, Vittoradolfo; Campanozzi, Laura; Magheri, Marco; Unali, Francesco; Bianchi, Martina; Benedetti, Francesca; Pascarella, Stefano; Angeletti, Silvia; Ciccozzi, Massimo. - In: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. - ISSN 1473-7159. - (2021). [10.1080/14737159.2021.1917998]

The importance of genomic analysis in cracking the Coronavirus pandemic

Ceccarelli, Giancarlo;D'Ettorre, Gabriella;Bianchi, Martina;Pascarella, Stefano;
2021

Abstract

Introduction: SARS-CoV-2 pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
2021
SARS-CoV-2; diagnosis; molecular epidemiology; pandemic; vaccine
01 Pubblicazione su rivista::01a Articolo in rivista
The importance of genomic analysis in cracking the Coronavirus pandemic / Zella, Davide; Giovanetti, Marta; Cella, Eleonora; Borsetti, Alessandra; Ciotti, Marco; Ceccarelli, Giancarlo; D'Ettorre, Gabriella; Pezzuto, Aldo; Tambone, Vittoradolfo; Campanozzi, Laura; Magheri, Marco; Unali, Francesco; Bianchi, Martina; Benedetti, Francesca; Pascarella, Stefano; Angeletti, Silvia; Ciccozzi, Massimo. - In: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. - ISSN 1473-7159. - (2021). [10.1080/14737159.2021.1917998]
File allegati a questo prodotto
File Dimensione Formato  
Zella_The importance_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.51 MB
Formato Adobe PDF
2.51 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1537374
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 9
social impact