Mikami et al. examine the role of miR-221/222 in helper T cells in the gut. MiR-221/222 are induced by IL-23 and suppressed by TGFβ, targeting Maf and IL23r for degradation. During inflammation, these miRNAs serve as a negative feedback rheostat to constrain IL23-Th17 cell responses.
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 / Mikami, Y.; Philips, R. L.; Sciumè, Giuseppe; Petermann, F.; Meylan, F.; Nagashima, H.; Yao, C.; Davis, F. P.; Brooks, S. R.; Sun, H. -W.; Takahashi, H.; Poholek, A. C.; Shih, H. -Y.; Afzali, B.; Muljo, S. A.; Hafner, M.; Kanno, Y.; O'Shea, J. J.. - In: IMMUNITY. - ISSN 1074-7613. - 54:3(2021), pp. 514-525.e6. [10.1016/j.immuni.2021.02.015]
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
Sciumè Giuseppe;
2021
Abstract
Mikami et al. examine the role of miR-221/222 in helper T cells in the gut. MiR-221/222 are induced by IL-23 and suppressed by TGFβ, targeting Maf and IL23r for degradation. During inflammation, these miRNAs serve as a negative feedback rheostat to constrain IL23-Th17 cell responses.| File | Dimensione | Formato | |
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