Mikami et al. examine the role of miR-221/222 in helper T cells in the gut. MiR-221/222 are induced by IL-23 and suppressed by TGFβ, targeting Maf and IL23r for degradation. During inflammation, these miRNAs serve as a negative feedback rheostat to constrain IL23-Th17 cell responses.
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 / Mikami, Y., Philips, R.L., Sciumè, G., Petermann, F., Meylan, F., Nagashima, H., Yao, C., Davis, F.P., Brooks, S.R., Sun, H.-W., Takahashi, H., Poholek, A.C., Shih, H.-Y., Afzali, B., Muljo, S.A., Hafner, M., Kanno, Y., O'Shea, J.J.. - In: IMMUNITY. - ISSN 1074-7613. - 54:3(2021), pp. 514-525.e6. [10.1016/j.immuni.2021.02.015]
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
Sciumè Giuseppe;
2021
Abstract
Mikami et al. examine the role of miR-221/222 in helper T cells in the gut. MiR-221/222 are induced by IL-23 and suppressed by TGFβ, targeting Maf and IL23r for degradation. During inflammation, these miRNAs serve as a negative feedback rheostat to constrain IL23-Th17 cell responses.| File | Dimensione | Formato | |
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