Objectives: The authors aimed to evaluate the role of N-terminal proANP (NT-proANP) and of NT-proBNP circulating levels as predictive markers of death due to systemic sclerosis (SSc).Methods: The authors retrospectively enrolled 51 SSc patients. At baseline, NT-proBNP and NT-proANP circulating levels and clinical features were collected. Date and causes of death were extracted during a 6-year follow-up.Results: 13 SSc patients (23.2%) died for SSc complications (9 for interstitial lung disease and 4 for pulmonary arterial hypertension). The median NT-proBNP plasma level did not significantly differ (p>0.05) in SSc patients died or alive [645 (448-1026) fmol/ml vs 592 (409-789) fmol/ml]. The median NT-proANP plasma level was significantly (p<0.01) higher in SSc died than in SSc patients alive [4000 (2100-6722) fmol/ml vs 1640 (1381-2721) fmol/ml]. The Kaplan-Meier analysis revealed that SSc patients with increased NT-proANP level had increased mortality (p<0.05). In the multivariate analysis, DLco [HR 0.966 (0.934-0.999), p <0.05] and NT-proANP level [HR 1 (1-1), p <0.05] were predictive markers of death due to SSc.Conclusions: NT-proANP plasma level is a predictive marker of death due to SSc.

Circulating NT-proANP level is a predictor of mortality for systemic sclerosis. a retrospective study of an Italian cohort / Romaniello, Antonella; Rubattu, Speranza; Vaiarello, Valentina; Gigante, Antonietta; Volpe, Massimo; Rosato, Edoardo. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-666X. - 17:6(2021), pp. 1-7. [10.1080/1744666X.2021.1908888]

Circulating NT-proANP level is a predictor of mortality for systemic sclerosis. a retrospective study of an Italian cohort

Rubattu, Speranza
Conceptualization
;
Vaiarello, Valentina
Investigation
;
Gigante, Antonietta
Investigation
;
Volpe, Massimo
Supervision
;
Rosato, Edoardo
Conceptualization
2021

Abstract

Objectives: The authors aimed to evaluate the role of N-terminal proANP (NT-proANP) and of NT-proBNP circulating levels as predictive markers of death due to systemic sclerosis (SSc).Methods: The authors retrospectively enrolled 51 SSc patients. At baseline, NT-proBNP and NT-proANP circulating levels and clinical features were collected. Date and causes of death were extracted during a 6-year follow-up.Results: 13 SSc patients (23.2%) died for SSc complications (9 for interstitial lung disease and 4 for pulmonary arterial hypertension). The median NT-proBNP plasma level did not significantly differ (p>0.05) in SSc patients died or alive [645 (448-1026) fmol/ml vs 592 (409-789) fmol/ml]. The median NT-proANP plasma level was significantly (p<0.01) higher in SSc died than in SSc patients alive [4000 (2100-6722) fmol/ml vs 1640 (1381-2721) fmol/ml]. The Kaplan-Meier analysis revealed that SSc patients with increased NT-proANP level had increased mortality (p<0.05). In the multivariate analysis, DLco [HR 0.966 (0.934-0.999), p <0.05] and NT-proANP level [HR 1 (1-1), p <0.05] were predictive markers of death due to SSc.Conclusions: NT-proANP plasma level is a predictive marker of death due to SSc.
2021
interstitial lung disease; mortality prediction; natriuretic peptides; pulmonary arterial hypertension; systemic sclerosis
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Circulating NT-proANP level is a predictor of mortality for systemic sclerosis. a retrospective study of an Italian cohort / Romaniello, Antonella; Rubattu, Speranza; Vaiarello, Valentina; Gigante, Antonietta; Volpe, Massimo; Rosato, Edoardo. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-666X. - 17:6(2021), pp. 1-7. [10.1080/1744666X.2021.1908888]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1532456
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