Acinetobacter baumannii is regarded as a life-threatening pathogen associated with community-acquired and nosocomial infections, mainly pneumonia. The rise in the number of A. baumannii antibiotic-resistant strains reduces effective therapies and increases mortality. Bacterial comparative genomic studies have unraveled the innate and acquired virulence factors of A. baumannii. These virulence factors are involved in antibiotic resistance, environmental persistence, host-pathogen interactions, and immune evasion. Studies on host–pathogen interactions revealed that A. baumannii evolved different mechanisms to adhere to in order to invade host respiratory cells as well as evade the host immune system. In this review, we discuss current data on A. baumannii genetic features and virulence factors. An emphasis is given to the players in host–pathogen interaction in the respiratory tract. In addition, we report recent investigations into host defense systems using in vitro and in vivo models, providing new insights into the innate immune response to A. baumannii infections. Increasing our knowledge of A. baumannii pathogenesis may help the development of novel therapeutic strategies based on anti-adhesive, anti-virulence, and anti-cell to cell signaling pathways drugs.

Acinetobacter baumannii. An ancient commensal with weapons of a pathogen / Sarsharjeryandeh, Meysam; Behzadi, Payam; Scribano, Daniela; Palamara, ANNA TERESA; Ambrosi, Cecilia. - In: PATHOGENS. - ISSN 2076-0817. - 10:4(2021), pp. 1-25. [10.3390/pathogens10040387]

Acinetobacter baumannii. An ancient commensal with weapons of a pathogen

Meysam Sarshar
Co-primo
;
Daniela Scribano
Co-primo
;
Anna Teresa Palamara;
2021

Abstract

Acinetobacter baumannii is regarded as a life-threatening pathogen associated with community-acquired and nosocomial infections, mainly pneumonia. The rise in the number of A. baumannii antibiotic-resistant strains reduces effective therapies and increases mortality. Bacterial comparative genomic studies have unraveled the innate and acquired virulence factors of A. baumannii. These virulence factors are involved in antibiotic resistance, environmental persistence, host-pathogen interactions, and immune evasion. Studies on host–pathogen interactions revealed that A. baumannii evolved different mechanisms to adhere to in order to invade host respiratory cells as well as evade the host immune system. In this review, we discuss current data on A. baumannii genetic features and virulence factors. An emphasis is given to the players in host–pathogen interaction in the respiratory tract. In addition, we report recent investigations into host defense systems using in vitro and in vivo models, providing new insights into the innate immune response to A. baumannii infections. Increasing our knowledge of A. baumannii pathogenesis may help the development of novel therapeutic strategies based on anti-adhesive, anti-virulence, and anti-cell to cell signaling pathways drugs.
acinetobacter baumannii; community-acquired infections; nosocomial infections; adherence; persistence; virulence factors; invasion; internalization
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Acinetobacter baumannii. An ancient commensal with weapons of a pathogen / Sarsharjeryandeh, Meysam; Behzadi, Payam; Scribano, Daniela; Palamara, ANNA TERESA; Ambrosi, Cecilia. - In: PATHOGENS. - ISSN 2076-0817. - 10:4(2021), pp. 1-25. [10.3390/pathogens10040387]
File allegati a questo prodotto
File Dimensione Formato  
Sarshar_Acinetobacter-baumannii_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.07 MB
Formato Adobe PDF
2.07 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1526625
Citazioni
  • ???jsp.display-item.citation.pmc??? 39
  • Scopus 52
  • ???jsp.display-item.citation.isi??? 50
social impact