Background and Aims Good glycemic control is crucial to reduce the risk of adverse pregnancy outcomes. Our aim was to evaluate the efficacy of Flash Glucose Monitoring (FGM) on glucose control in women with pregestational diabetes. Methods and Results Forty women with inadequately controlled type 1 (T1D, n=34) and type 2 (T2D, n=6) diabetes at conception were randomly assigned to two arms: the Flash Glucose group (FG, n=21) using FGM, and the control group (CG, n=19) using self-monitoring of blood glucose (SMBG). Glycated hemoglobin (HbA1c, %), time in (TIR), below (TBR) and above (TAR) range, glucose variability as well as the occurrence of maternal and neonatal adverse outcomes, were evaluated. HbA1c decreased significantly (p<0.01) and similarly (-0.65±0.7 vs. -0.67±0.8 for FG and CG, respectively; p=0.89) in both groups during pregnancy. HbA1c reduction was positively associated with the number of daily FGM scans (p<0.01). TBR (12.1±2.0% vs. 19.6±3.9%, p=0.04) and the mean of the daily serum glucose difference (MODD) index (59.1±5.4 vs. 77.7±4.6, p=0.02) were significantly lower in FG at second trimester. The rates of perinatal adverse outcomes were not different in the two studied groups. Conclusions In women with pregestational diabetes, FGM and SMBG had similar efficacy on glucose control during pregnancy. FGM showed additional advantages in terms of TBR and glucose variability. Achievement of good metabolic results depended on the adequate use of glucose sensor.

Efficacy of flash glucose monitoring in pregnant women with poorly controlled pregestational diabetes (flashmom): a randomized pilot study / Tumminia, Andrea; Milluzzo, Agostino; Festa, Camilla; Fresa, Raffaella; Pintaudi, Basilio; Scavini, Marina; Vitacolonna, Ester; Napoli, Angela; Sciacca, Laura. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - (2021), pp. 1-9. [10.1016/j.numecd.2021.03.013]

Efficacy of flash glucose monitoring in pregnant women with poorly controlled pregestational diabetes (flashmom): a randomized pilot study

Festa, Camilla;Napoli, Angela;
2021

Abstract

Background and Aims Good glycemic control is crucial to reduce the risk of adverse pregnancy outcomes. Our aim was to evaluate the efficacy of Flash Glucose Monitoring (FGM) on glucose control in women with pregestational diabetes. Methods and Results Forty women with inadequately controlled type 1 (T1D, n=34) and type 2 (T2D, n=6) diabetes at conception were randomly assigned to two arms: the Flash Glucose group (FG, n=21) using FGM, and the control group (CG, n=19) using self-monitoring of blood glucose (SMBG). Glycated hemoglobin (HbA1c, %), time in (TIR), below (TBR) and above (TAR) range, glucose variability as well as the occurrence of maternal and neonatal adverse outcomes, were evaluated. HbA1c decreased significantly (p<0.01) and similarly (-0.65±0.7 vs. -0.67±0.8 for FG and CG, respectively; p=0.89) in both groups during pregnancy. HbA1c reduction was positively associated with the number of daily FGM scans (p<0.01). TBR (12.1±2.0% vs. 19.6±3.9%, p=0.04) and the mean of the daily serum glucose difference (MODD) index (59.1±5.4 vs. 77.7±4.6, p=0.02) were significantly lower in FG at second trimester. The rates of perinatal adverse outcomes were not different in the two studied groups. Conclusions In women with pregestational diabetes, FGM and SMBG had similar efficacy on glucose control during pregnancy. FGM showed additional advantages in terms of TBR and glucose variability. Achievement of good metabolic results depended on the adequate use of glucose sensor.
2021
flash glucose monitoring; pregestational diabetes; glucose control; HbA1c; glycemic variability; adverse pregnancy outcomes
01 Pubblicazione su rivista::01a Articolo in rivista
Efficacy of flash glucose monitoring in pregnant women with poorly controlled pregestational diabetes (flashmom): a randomized pilot study / Tumminia, Andrea; Milluzzo, Agostino; Festa, Camilla; Fresa, Raffaella; Pintaudi, Basilio; Scavini, Marina; Vitacolonna, Ester; Napoli, Angela; Sciacca, Laura. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - (2021), pp. 1-9. [10.1016/j.numecd.2021.03.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1526618
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