OBJECTIVES: To identify the cochlear segment in which spiral ganglion neuron (SGN) loss may more severely impact discrimination thresholds. MATERIALS and METHODS: Thirteen temporal bones from 13 subjects between 55 and 77 years of age were analyzed. The organ of corti was analyzed to identify the loss of hair cells, and the number of SGNs in each cochlear segment were counted. The results of the speech perception test (SPT) and pure tone audiometry (PTA) tests were collected. PTA averages for low and high frequencies were calculated. One-way analysis of variance (ANOVA), Pearson, Spearman, and multilinear regression tests were performed. RESULTS: No statistically significant correlation was identified between the patient’s age and number of SGNs. Statistically significant differences were observed between the number of SGNs in the different cochlear segments (one-way ANOVA: p<0.0001) and between poor PTA average and SPT scores (negative correlation) (p=0.03). A statistically significant correlation was identified between the overall number of cochlear SGNs and SPT scores (p=0.02) and between the number of SGNs in cochlear segments I (p=0.04) and II and the SPT score (p=0.03). CONCLUSIONS: We identified that residual SGNs in the basal and middle turns of the cochlea might be determinants of speech perception.

Spiral ganglions and speech perception in the elderly. Which turn of the cochlea is the more relevant? a preliminary study on human temporal bones / Di Stadio, A.; della Volpe, A.; Ralli, M.; Korsch, F.; Greco, A.; Ricci, G.. - In: THE JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY. - ISSN 1308-7649. - 16:3(2020), pp. 318-322. [10.5152/iao.2020.8481]

Spiral ganglions and speech perception in the elderly. Which turn of the cochlea is the more relevant? a preliminary study on human temporal bones

Di Stadio A.
Primo
;
Ralli M.;Greco A.
Penultimo
;
2020

Abstract

OBJECTIVES: To identify the cochlear segment in which spiral ganglion neuron (SGN) loss may more severely impact discrimination thresholds. MATERIALS and METHODS: Thirteen temporal bones from 13 subjects between 55 and 77 years of age were analyzed. The organ of corti was analyzed to identify the loss of hair cells, and the number of SGNs in each cochlear segment were counted. The results of the speech perception test (SPT) and pure tone audiometry (PTA) tests were collected. PTA averages for low and high frequencies were calculated. One-way analysis of variance (ANOVA), Pearson, Spearman, and multilinear regression tests were performed. RESULTS: No statistically significant correlation was identified between the patient’s age and number of SGNs. Statistically significant differences were observed between the number of SGNs in the different cochlear segments (one-way ANOVA: p<0.0001) and between poor PTA average and SPT scores (negative correlation) (p=0.03). A statistically significant correlation was identified between the overall number of cochlear SGNs and SPT scores (p=0.02) and between the number of SGNs in cochlear segments I (p=0.04) and II and the SPT score (p=0.03). CONCLUSIONS: We identified that residual SGNs in the basal and middle turns of the cochlea might be determinants of speech perception.
2020
Cochlea segmentation; Speech perception; Spiral ganglions; Word understanding
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Spiral ganglions and speech perception in the elderly. Which turn of the cochlea is the more relevant? a preliminary study on human temporal bones / Di Stadio, A.; della Volpe, A.; Ralli, M.; Korsch, F.; Greco, A.; Ricci, G.. - In: THE JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY. - ISSN 1308-7649. - 16:3(2020), pp. 318-322. [10.5152/iao.2020.8481]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1524893
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