CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) regimens for HIV-infected individuals. Polymorphisms of the CYP2B6 gene influence drug levels in plasma and possibly virological outcomes. The aim of this study was to explore the potential impact of CYP2B6 genotype and haplotype variation on the risk of developing EFV/NVP drug resistance mutations (DRMs) in HIV-1 patients receiving EFV-/NVP-containing regimens in Botswana.
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana / Maseng, Monkgomotsi J; Tawe, Leabaneng; Thami, Prisca K; Seatla, Kaelo K; Moyo, Sikhulile; Martinelli, Axel; Kasvosve, Ishmael; Novitsky, Vladimir; Essex, Max; Russo, Gianluca; Gaseitsiwe, Simani; Paganotti, Giacomo M. - In: PHARMACOGENOMICS AND PERSONALIZED MEDICINE. - ISSN 1178-7066. - 14:(2021), pp. 335-347. [10.2147/PGPM.S289471]
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana
Russo, GianlucaUltimo
;Paganotti, Giacomo M
2021
Abstract
CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) regimens for HIV-infected individuals. Polymorphisms of the CYP2B6 gene influence drug levels in plasma and possibly virological outcomes. The aim of this study was to explore the potential impact of CYP2B6 genotype and haplotype variation on the risk of developing EFV/NVP drug resistance mutations (DRMs) in HIV-1 patients receiving EFV-/NVP-containing regimens in Botswana.| File | Dimensione | Formato | |
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