Background/Aim: Endoluminal self-expanding metallic stents (SEMS) may overcome the risk of mortality and morbidity of acute intestinal obstruction because of stage IV colon (CC) or rectal (RC) cancer. We evaluated the QoL in these groups of patients. Patients and Methods: Forty-eight patients were enrolled in a prospective longitudinal cohort single-center trial to undergo SEMS positioning. Twenty-five patients had a CC and 23 RC. Karnofsky performance scale, Visual Analogue Scale and the EQ-5D- 5LTM questionnaire were administered before treatment and at 1, 3 and 6 months. Results: Harmonized to the Italian population, the index values showed a statistically significant deterioration of the QoL in patients with RC when compared to those with CC at 1-, 3- and 6-months (1 month: p=0.001; 3- month: p=0.001; 6-month: p=0.045). Similarly, Visual Analogue Scale showed variations at 1- (p=0.008), 3- (p=0.001) and 6-months (p=0.020). Rectal stent deployment was the only independent predictor for a worse QoL in all domains (p<0.017; OR=0.196; 95%CI=0.51-0.749). Conclusion: Patients affected with stage IV CC had a better QoL after SEMS placement when compared to those affected with RC. The persistency of the primary tumor at the rectal level, even if irradiated, might negatively affect QoL.

Colon or rectal stent positioning for advanced cancer influences quality of life: a critical point of view / Fiori, Enrico; Crocetti, Daniele; Sapienza, Paolo; Miccini, Michelangelo; Cirocchi, Roberto; Sterpetti, ANTONIO V.; DE FELICE, Francesca; Costi, Silvano; Brachini, Gioia; Mingoli, Andrea; Lamazza, Antonietta; DE TOMA, Giorgio. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 41:4(2021), pp. 1945-1950. [10.21873/anticanres.14961]

Colon or rectal stent positioning for advanced cancer influences quality of life: a critical point of view

ENRICO FIORI
Primo
;
DANIELE CROCETTI
Secondo
;
PAOLO SAPIENZA;MICHELANGELO MICCINI;ANTONIO V. STERPETTI;FRANCESCA DE FELICE;GIOIA BRACHINI;ANDREA MINGOLI;ANTONIETTA LAMAZZA
Penultimo
;
GIORGIO DE TOMA
Ultimo
2021

Abstract

Background/Aim: Endoluminal self-expanding metallic stents (SEMS) may overcome the risk of mortality and morbidity of acute intestinal obstruction because of stage IV colon (CC) or rectal (RC) cancer. We evaluated the QoL in these groups of patients. Patients and Methods: Forty-eight patients were enrolled in a prospective longitudinal cohort single-center trial to undergo SEMS positioning. Twenty-five patients had a CC and 23 RC. Karnofsky performance scale, Visual Analogue Scale and the EQ-5D- 5LTM questionnaire were administered before treatment and at 1, 3 and 6 months. Results: Harmonized to the Italian population, the index values showed a statistically significant deterioration of the QoL in patients with RC when compared to those with CC at 1-, 3- and 6-months (1 month: p=0.001; 3- month: p=0.001; 6-month: p=0.045). Similarly, Visual Analogue Scale showed variations at 1- (p=0.008), 3- (p=0.001) and 6-months (p=0.020). Rectal stent deployment was the only independent predictor for a worse QoL in all domains (p<0.017; OR=0.196; 95%CI=0.51-0.749). Conclusion: Patients affected with stage IV CC had a better QoL after SEMS placement when compared to those affected with RC. The persistency of the primary tumor at the rectal level, even if irradiated, might negatively affect QoL.
advanced colorectal cancer; endoscopic stent positioning; surgical resection; quality of Life (QoL)
01 Pubblicazione su rivista::01a Articolo in rivista
Colon or rectal stent positioning for advanced cancer influences quality of life: a critical point of view / Fiori, Enrico; Crocetti, Daniele; Sapienza, Paolo; Miccini, Michelangelo; Cirocchi, Roberto; Sterpetti, ANTONIO V.; DE FELICE, Francesca; Costi, Silvano; Brachini, Gioia; Mingoli, Andrea; Lamazza, Antonietta; DE TOMA, Giorgio. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 41:4(2021), pp. 1945-1950. [10.21873/anticanres.14961]
File allegati a questo prodotto
File Dimensione Formato  
Fiori_Colon_2021.pdf

accesso aperto

Note: https://ar.iiarjournals.org/content/41/4/1945
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 107.57 kB
Formato Adobe PDF
107.57 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1517664
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact