Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their role is still a matter of controversy as far as Gram negative bacteremias are concerned. We revised, analyzed, and commented on the literature addressing this issue, to define the clinical settings in which the application of FUBCs could better reveal its value. The results of this review show that critically ill patients, endovascular and/or non-eradicable source of infection, isolation of a multi-drug resistant pathogen, end-stage renal disease, and immunodeficiencies are some factors that may predispose patients to persistent Gram negative bacteremia. An analysis of the different burdens that each of these factors have in this clinical setting allowed us to suggest which patients’ FUBCs have the potential to modify treatment choices, prompt an early source control, and finally, improve clinical outcome.

Are Follow-Up Blood Cultures useful in the antimicrobial management of gram negative bacteremia? A reappraisal of their role based on current knowledge / COGLIATI DEZZA, Francesco; Curtolo, Ambrogio; Volpicelli, Lorenzo; Ceccarelli, Giancarlo; Oliva, Alessandra; Venditti, Mario. - In: ANTIBIOTICS. - ISSN 2079-6382. - (2020).

Are Follow-Up Blood Cultures useful in the antimicrobial management of gram negative bacteremia? A reappraisal of their role based on current knowledge

Francesco Cogliati Dezza
Co-primo
Writing – Original Draft Preparation
;
† Ambrogio Curtolo
Co-primo
Writing – Original Draft Preparation
;
† Lorenzo Volpicelli
Co-primo
Writing – Original Draft Preparation
;
† Giancarlo Ceccarelli
Supervision
;
Alessandra Oliva
Penultimo
Supervision
;
Mario Venditti
Ultimo
Conceptualization
2020

Abstract

Bloodstream infections still constitute an outstanding cause of in-hospital morbidity and mortality, especially among critically ill patients. Follow up blood cultures (FUBCs) are widely recommended for proper management of Staphylococcus aureus and Candida spp. infections. On the other hand, their role is still a matter of controversy as far as Gram negative bacteremias are concerned. We revised, analyzed, and commented on the literature addressing this issue, to define the clinical settings in which the application of FUBCs could better reveal its value. The results of this review show that critically ill patients, endovascular and/or non-eradicable source of infection, isolation of a multi-drug resistant pathogen, end-stage renal disease, and immunodeficiencies are some factors that may predispose patients to persistent Gram negative bacteremia. An analysis of the different burdens that each of these factors have in this clinical setting allowed us to suggest which patients’ FUBCs have the potential to modify treatment choices, prompt an early source control, and finally, improve clinical outcome.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1512493
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