Objective: To evaluate determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection. Materials and methods: Hospitalized patients with SARS-CoV-2 positive nasopharyngeal RT-PCR were included in a single-center, retrospective study. Patients were divided in 2 groups according to the timing of viral clearance [≤14 days, “early clearance (EC)” and >14 days, “late clearance (LC)”]. Results: 179 patients were included in the study (101 EC, 78 LC), with median age 62 years. Median time of viral shedding was 14 days (EC/LC 10 and 19 days, respectively, P < 0.0001). Univariate analyses showed that age, male gender, receiving corticosteroids, receiving tocilizumab, ICU admission, low albumin and NLR ratio were associated with late viral clearance. In the multivariable analysis, older age (P = 0.016), albumin level (P = 0.048), corticosteroids (P = 0.021), and tocilizumab (P = 0.015) were significantly associated with late viral clearance. Conclusions: Age, albumin, tocilizumab and corticosteroid treatment were independently associated with a prolonged SARS-CoV-2 RNA shedding.

Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection / COGLIATI DEZZA, Francesco; Oliva, A.; Cancelli, F.; Savelloni, G.; Valeri, S.; Mauro, V.; Calabretto, M.; Russo, G.; Venditti, M.; Turriziani, O.; Mastroianni, C. M.. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - (2021).

Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection

Francesco Cogliati Dezza
Primo
;
A. Oliva
Secondo
;
F. Cancelli;G. Savelloni;S. Valeri;V. Mauro;M. Calabretto;G. Russo;M. Venditti;O. Turriziani
Penultimo
;
C. M. Mastroianni
Ultimo
2021

Abstract

Objective: To evaluate determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection. Materials and methods: Hospitalized patients with SARS-CoV-2 positive nasopharyngeal RT-PCR were included in a single-center, retrospective study. Patients were divided in 2 groups according to the timing of viral clearance [≤14 days, “early clearance (EC)” and >14 days, “late clearance (LC)”]. Results: 179 patients were included in the study (101 EC, 78 LC), with median age 62 years. Median time of viral shedding was 14 days (EC/LC 10 and 19 days, respectively, P < 0.0001). Univariate analyses showed that age, male gender, receiving corticosteroids, receiving tocilizumab, ICU admission, low albumin and NLR ratio were associated with late viral clearance. In the multivariable analysis, older age (P = 0.016), albumin level (P = 0.048), corticosteroids (P = 0.021), and tocilizumab (P = 0.015) were significantly associated with late viral clearance. Conclusions: Age, albumin, tocilizumab and corticosteroid treatment were independently associated with a prolonged SARS-CoV-2 RNA shedding.
2021
Viral shedding; SARS-CoV-2; tocilizumab; steroids; ICU admission
01 Pubblicazione su rivista::01a Articolo in rivista
Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection / COGLIATI DEZZA, Francesco; Oliva, A.; Cancelli, F.; Savelloni, G.; Valeri, S.; Mauro, V.; Calabretto, M.; Russo, G.; Venditti, M.; Turriziani, O.; Mastroianni, C. M.. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - (2021).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1512183
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