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Objective To compare disease course in patients with Guillain-Barré syndrome (GBS) with a poor prognosis who were treated with one or with two intravenous immunoglobulin (IVIg) courses. Methods From the International GBS Outcome Study, we selected patients whose modified Erasmus GBS Outcome Score at week 1 predicted a poor prognosis. We compared those treated with one IVIg course to those treated with two IVIg courses. The primary endpoint, the GBS disability scale at 4 weeks, was assessed with multivariable ordinal regression. Results Of 237 eligible patients, 199 patients received a single IVIg course. Twenty patients received an α early' second IVIg course (1-2 weeks after start of the first IVIg course) and 18 patients a α late' second IVIg course (2-4 weeks after start of IVIg). At baseline and 1 week, those receiving two IVIg courses were more disabled than those receiving one course. Compared with the one course group, the adjusted OR for a better GBS disability score at 4 weeks was 0.70 (95%CI 0.16 to 3.04) for the early group and 0.66 (95%CI 0.18 to 2.50) for the late group. The secondary endpoints were not in favour of a second IVIg course. Conclusions This observational study did not show better outcomes after a second IVIg course in GBS with poor prognosis. The study was limited by small numbers and baseline imbalances. Lack of improvement was likely an incentive to start a second IVIg course. A prospective randomised trial is needed to evaluate whether a second IVIg course improves outcome in GBS.
Second IVIg course in Guillain-Barré syndrome with poor prognosis. The non-randomised ISID study / C., Verboon; B., Van Den Berg; D. R., Cornblath; E., Venema; K. C., Gorson; M. P., Lunn; H., Lingsma; P., Van Den Bergh; T., Harbo; K., Bateman; Y., Pereon; So. H., Sindrup; S., Kusunoki; J., Miller; Z., Islam; H. -P., Hartung; G., Chavada; B. C., Jacobs; R. A. C., Hughes; Addington, Van Doorn P. A. J. M.; (University of Virginia, Md; USA), Charlottesville; on October 7, S. Consortia. Protected by copyright.; Downloaded from 8 Verboon C, 2019 at Uppsala Universitet BIBSAM http://jnnp. bmj. com/ J Neurol Neurosurg Psychiatry: first published as 10. 1136/jnnp-2019-321496 on 5 October 2019.; J Neurol Neurosurg Psychiatry 2019, et al.; 1136/jnnp-2019-321496 Neuromuscular Ajroud-Driss, 0:1–9. doi:10.; (Northwestern University Feinberg, Md; USA), Chicago; Antonini, G.; (Mental Health and Sensory Organs (NESMOS), Md; University, Sapienza; Hospital, Sant’Andrea; Italy), Rome; Attarian, S.; Md, ; (CHU Timone, Phd; France), Marseille; Barroso, F. A.; (Instituto de Investigaciones Neurológicas Raúl Carrea, Md; Fleni, ; Aires, Buenos; Argentina), ; Benedetti, L.; Md, ; (Ospedale Sant’ Andrea La Spezia, Phd; Spezia, La; Italy), ; Bertorini, T. E.; (The University of Tennessee Health Science Center (UTHSC), Md; USA), Memphis; Brannagan, T. H.; (Columbia University, Md; York City, New; USA), ; Briani, C.; (University of Padova, Md; Italy), Padova; Bhavaraju-Sanka, R.; (University Hospital/University of Texas Health Science Center, Md; Antonio Texas, San; USA), ; Butterworth, S.; (Pinderfields Hospital, Md; UK), Wakefield; Casasnovas, C.; Md, ; Ciberer, PhD (Bellvitge University Hospital – IDIBELL Neurometabolic Diseases Group.; Spain), Barcelona; Cavaletti, G.; (University Milano-Bicocca, Md; Italy), Monza; Chen, S.; Md, ; (Rutgers, Phd; Wood Johnson University Hospital, Robert; Brunswick, New; USA), ; Claeys, K. G.; Md, ; University Hospitals Leuven, PhD (1.; Belgium, Leuven; KU Leuven, 2.; Belgium), Leuven; Cosgrove, J. S.; (Leeds General Infirmary, Md; UK), Leeds; Davidson, A.; (University of Glasgow, Md; UK), Glasgow; Dardiotis, E.; (University of Thessaly, Md; of Larissa, Hospital; Greece), Larissa; Dornonville de la Cour, C.; (National Hospital Copenhagen, Md; Denmark), Copenhagen; Faber, C. G.; Md, ; (Maastricht University Medical Centre, Phd; Maastricht, ; Netherlands), The; Feasby, T. E.; (University of Calgary, Md; Canada), Calgary; Fujioka, T.; (Toho University Medical Center, Md; Japan), Tokyo; Galassi, G.; (University Hospital of Modena, Md; Italy), Modena; Gilchrist, J. M.; (Soulthern Illinois University School of Medicine, Md; USA), Springfield; Goyal, N. A.; (University of California, Md; USA), Irvine; Granit, V.; (Montefiore Medical, Md; Center, ; York, New; USA), ; Gutiérrez-Gutiérrez, G.; (Hospital Universitario Infanta Sofia, Md; Sebastian, San; Spain), ; Hadden, R. D. M.; Md, ; (King’s College Hospital, Phd; UK), London; Holt, J. K. L.; Phd, ; (The Walton Centre, Frcp; UK), Liverpool; Htut, M.; George’s Hospital, MD (St.; UK), London; Jericó Pascual, I.; Md, ; (Complejo Hospitalario de Navarra, Phd; Spain), Pamplona; Karafiath, S.; (University of Utah School of Medicine, Md; Lake City, Salt; USA), ; Katzberg, H. D.; (University of Toronto, Md; Canada), Toronto; Kiers, L.; (University of Melbourne, Md; Melbourne Hospital, Royal; Australia), Parkville; Kieseier, B. C.; (Heinrich Heine University, Md; Germany), Düsseldorf; Kimpinski, K.; (University Hospital, Md; London-Ontario, Lhsc; Canada), ; Kuwabara, S.; Md, ; (Chiba University, Phd; Japan), Chiba; Kwan, J. Y.; (University of Maryland School of Medicine, Md; USA), Baltimore; Ladha, S. S.; (Barrow Neurology Clinics, Md; Arizona, Phoenix; USA), ; Lawson, V.; (Wexner Medical Center at The Ohio State University, Md; USA), Columbus; Lehmann, H.; Md, ; (University Hospital of Cologne, Phd; Köln, Universitätsklinikum; Germany), Cologne; Manji, H.; Md, ; (Ipswich Hospital, Frcp; UK), Ipswich; Marfia, G. A.; (Neurological Clinic, Md; Tor Vergata, Policlinico; Italy), Rome; Márquez Infante, C.; (Hospital Universitario Virgen del Rocio, Md; Spain), Seville; Mattiazzi, M. G.; (Hospital Militar Central, Md; Aires, Buenos; Argentina), ; Mcdermott, C. J.; (Royal Hallamshire Hospital, Md; Clinical, Nihr; UK), Sheffield; Monges, M. S.; Garrahan, MD (Hospital de Pediatría J. P.; Aires, Buenos; Argentina), ; Morís de la Tassa, G.; (Hospital Universitario Central de Asturias, Md; Spain), Asturias; Nascimbene, C.; Md, ; (Luigi Sacco Hospital, Phd; Italy), Milan; Nobile Orazio, E.; Md, ; (Milan University, Phd; Clinicala and Research Institute Milan, Humanitas; Italy), ; Nowak, R. J.; (Yale University School of Medicine, Md; Haven, New; USA), ; Osei-Bonsu (James Cook University Hospital, M.; UK), Middlesbrough; Pardo Fernandez (Hospital Clínico de Santiago, J.; de Compostela (A Coruña), Santiago; Spain), ; Querol Gutierrez, L.; Md, ; i Sant Pau, PhD (Hospital de la Santa Creu; Autònoma de Barcelona, Universitat; Spain), Barcelona; Reisin (Hospital Britanico, R.; Aires, Buenos; Argentina), ; Rinaldi, S.; Mbchb, ; Roberts, PhD (University of Oxford R. C.; (Addenbrooke’s Hospital Cambridge, Md; UK), Cambridge; Rojas-Marcos, I.; (Hospital Univesitario Reina Sofia, Md; Spain), Cordoba; Rudnicki, S. A.; (University of Arkansas, Md; USA), Fayetteville; Schenone, A.; Md, ; Department of Neurosciences, PhD (1.; Ophthalmology, Rehabilitation; and Maternal and Infantile Sciences (DINOGMI), Genetics; of Genova, University; Genova, ; IRCCS Policlinico San Martino, Italy 2.; Italy), Genova; Sedano Tous, M. J.; (Hospital Universitario Marques de Valdecilla, Md; Cantabria, Santander; Spain), ; Shahrizaila, N.; (Neurology Unit, Md; of Medicine, Department; of Medicine, Faculty; of Malaya, University; Malaya), ; Sheikh, K.; Md, ; (The University of Texas Health Science Center at Houston, Phd; USA), Houston; Silvestri, N. J.; (Buffalo General Medical Center, Md; Ny, Buffalo; USA), ; Sommer, C. L.; (Universitätsklinikum Würzburg, Md; Germany), Würzburg; Varrato, J. D.; (Lehigh Valley Health Network, Do; USA), Allentown; Verschuuren, J.; Md, ; (Leiden University Medical Centre, Phd; Leiden, ; Netherlands), The; Vytopil, M. V.; Md, ; Waheed, PhD (Tufts University School of Medicine Lahey Hospital W.; (University of Vermont Medical Center, Md; USA), Burlington; Zhou, L.; Md, ; (Icahn School of Medicine at Mount Sinai, Phd; York, New; Badrising, USA). Other collaborators were:U. A.; Md, ; (Leiden University Medical Centre, Phd; Leiden, ; Netherlands), The; Bella, I. R.; (University of Mass Medical School, Md; USA), Worcester; Bunschoten, C.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Bürmann, J.; Md, ; des Saarlandes, Universitätsklinikum; Germany), Homburg; Busby, M.; (Leeds General Infirmary, Md; UK), Bradford; Chao, C. C.; Md, ; (National Taiwan University Hospital, Phd; Taiwan), Taipei; Conti, M. E.; (University Hospital Clinicas, Md; Aires, Buenos; Argentina), ; Dalakas, M. C.; Thomas Jefferson University, MD (1.; Usa, Philadelphia; National and Kapodistrian University of Athens, 2.; Greece), Athens; Van Damme, P.; Md, ; (University Hospital Leuven, Phd; Belgium), Leuven; Doets, A.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; van Dijk, G. W.; (Canisius Wilhelmina Hospital, Md; Nijmegen, ; Netherlands), The; Dimachkie, M. M.; (University of Kansas Medical Center, Md; City, Kansas; USA), ; Doppler, K.; (Universitätsklinikum Würzburg, Md; Germany), Würzburg; Echaniz-Laguna, A.; (Hopital de Hautepierre, Md; France), Strasbourgh; Eftimov, F.; Md, ; (Amsterdam University Medical Centre, Phd; Amsterdam, ; Netherlands), The; Fazio, R.; (Scientific Institute San Raffaele, Md; Italy), Milan; Fokke, C.; (Gelre Hospital, Md; and Apeldoorn, Zutphen; Netherlands), The; Fulgenzi, E. A.; (Hospital Cesar Milstein Buenos Aires, Md; Aires, Buenos; Argentina), ; Garssen, M. P. J.; Md, ; (Jeroen Bosch Hospital, Phd; Hertogenbosch, ’S; and Drunen, Zaltbommel; Netherlands), The; Gijsbers, C. J.; (Vlietland Hospital, Md; Schiedam, ; Netherlands), The; Gilhuis, J.; Md, ; (Reinier de Graaf Gasthuis, Phd; Delft, ; Netherlands), The; Grapperon, A.; (CHU Timone, Md; France), Marseille; Hsieh, S. T.; Md, ; (National Taiwan University Hospital, Phd; Taiwan), Taipei; Illa, I.; Md, ; i Sant Pau, PhD (Hospital de la Santa Creu; Autònoma de Barcelona, Universitat; Spain), Barcelona; Islam, B.; Md, ; (International Centre for Diarrhoeal Disease Research, Phd; (icddr, Bangladesh; Dhaka, b); Bangladesh), ; Jellema, K.; Md, ; (Haaglanden Medisch Centrum, Phd; Hague, The; Netherlands), The; Kaida, K.; Md, ; (National Defense Medical College, Phd; Japan), Saitama; Kokubun, N.; (Dokkyo Medical University, Md; Japan), Tochigi; Kolb, N.; (University of Vermont, Md; Vt, Burlington; USA), ; van Koningsveld, R.; Md, ; (Elkerliek Hospital, Phd; and Deurne, Helmond; Netherlands), The; van der Kooi, A. J.; Md, ; (Amsterdam University Medical Centre, Phd; Amsterdam, ; Netherlands), The; Kuitwaard, K.; Md, ; (Albert Schweitzer Hospital, Phd; Dordrecht, ; Netherlands), The; Landschoff Lassen, L.; (Glostrup Hospital, Md; Denmark), Glostrup; Leonhard, S. E.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Mandarakas, M.; Md, ; (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Martinez Hernandez, E.; i Sunyer (IDIBAPS), MD (Institut d’Investigacions Biomèdiques August Pi; Clinic, Hospital; Spain), Barcelona; Mohammad, Q. D.; Md, ; (National Institute of Neurosciences and Hospital, Phd; Bangladesh), Dhaka; Pulley, M.; (University of Florida, Md; USA), Jacksonville; Rajabally, Y. A.; Md, ; (Queen Elizabeth Hospital, Phd; UK), Birmingham; Reddel, S. W.; Md, ; (Concord Repatriation General Hospital, Phd; Australia), Sydney; van der Ree, T.; (Westfriesgasthuis, Md; Hoorn, ; Netherlands), The; Roodbol, J.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Sachs, G. M.; (University of Rhode Island, Md; USA), Providence; Samijn, J. P. A.; Md, ; (Maasstad Hospital, Phd; Rotterdam, ; Netherlands), The; Santoro, L.; Md, ; (University Federico II, Phd; Italy), Napels; Stein, B.; Joseph’s Regional Medical Center, MD (St.; USA), Paterson; Vermeij, F. H.; (Franciscus Gasthuis, Md; Rotterdam, ; Netherlands), The; Visser, L. H.; Md, ; (Elisabeth-TweeSteden Hospital, Phd; and Waalwijk, Tilburg; Netherlands), The; Willison, H. J.; Md, ; (University of Glasgow, Phd; UK), Glasgow; Wirtz, P.; Md, ; (HagaZiekenhuis, Phd; Hague, The; Netherlands), The; Zivkovich, S. A.; Md, ; (University of Pittsburgh Medical Center, Phd; USA)., Pittsburgh. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - 91:2(2020), pp. 1-9. [10.1136/jnnp-2019-321496]
Second IVIg course in Guillain-Barré syndrome with poor prognosis. The non-randomised ISID study
Verboon C.;Van Den Berg B.;Cornblath D. R.;Venema E.;Gorson K. C.;Lunn M. P.;Lingsma H.;Van Den Bergh P.;Harbo T.;Bateman K.;Pereon Y.;Sindrup So. H.;Kusunoki S.;Miller J.;Islam Z.;Hartung H. -P.;Chavada G.;Jacobs B. C.;Hughes R. A. C.;Van Doorn P. A. J. M. Addington;MD (University of Virginia;Charlottesville USA);S. Consortia. Protected by copyright. on October 7;2019 at Uppsala Universitet BIBSAM http://jnnp. bmj. com/ J Neurol Neurosurg Psychiatry: first published as 10. 1136/jnnp-2019-321496 on 5 October 2019. Downloaded from 8 Verboon C;et al. J Neurol Neurosurg Psychiatry 2019;0:1–9. doi:10. 1136/jnnp-2019-321496 Neuromuscular Ajroud-Driss;MD (Northwestern University Feinberg;Chicago USA);G. Antonini;MD (Mental Health and Sensory Organs (NESMOS);Sapienza University;Sant’Andrea Hospital;Rome Italy);S. Attarian;MD;PhD (CHU Timone;Marseille France);F. A. Barroso;MD (Instituto de Investigaciones Neurológicas Raúl Carrea;FLENI;Buenos Aires;Argentina);L. Benedetti;MD;PhD (Ospedale Sant’ Andrea La Spezia;La Spezia;Italy);T. E. Bertorini;MD (The University of Tennessee Health Science Center (UTHSC);Memphis USA);T. H. Brannagan;MD (Columbia University;New York City;USA);C. Briani;MD (University of Padova;Padova Italy);R. Bhavaraju-Sanka;MD (University Hospital/University of Texas Health Science Center;San Antonio Texas;USA);S. Butterworth;MD (Pinderfields Hospital;Wakefield UK);C. Casasnovas;MD;PhD (Bellvitge University Hospital – IDIBELL Neurometabolic Diseases Group. CIBERER;Barcelona Spain);G. Cavaletti;MD (University Milano-Bicocca;Monza Italy);S. Chen;MD;PhD (Rutgers;Robert Wood Johnson University Hospital;New Brunswick;USA);K. G. Claeys;MD;PhD (1. University Hospitals Leuven;Leuven Belgium;2. KU Leuven;Leuven Belgium);J. S. Cosgrove;MD (Leeds General Infirmary;Leeds UK);A. Davidson;MD (University of Glasgow;Glasgow UK);E. Dardiotis;MD (University of Thessaly;Hospital of Larissa;Larissa Greece);C. Dornonville de la Cour;MD (National Hospital Copenhagen;Copenhagen Denmark);C. G. Faber;MD;PhD (Maastricht University Medical Centre;Maastricht;The Netherlands);T. E. Feasby;MD (University of Calgary;Calgary Canada);T. Fujioka;MD (Toho University Medical Center;Tokyo Japan);G. Galassi;MD (University Hospital of Modena;Modena Italy);J. M. Gilchrist;MD (Soulthern Illinois University School of Medicine;Springfield USA);N. A. Goyal;MD (University of California;Irvine USA);V. Granit;MD (Montefiore Medical;Center;New York;USA);G. Gutiérrez-Gutiérrez;MD (Hospital Universitario Infanta Sofia;San Sebastian;Spain);R. D. M. Hadden;MD;PhD (King’s College Hospital;London UK);J. K. L. Holt;PhD;FRCP (The Walton Centre;Liverpool UK);M. Htut;MD (St. George’s Hospital;London UK);I. Jericó Pascual;MD;PhD (Complejo Hospitalario de Navarra;Pamplona Spain);S. Karafiath;MD (University of Utah School of Medicine;Salt Lake City;USA);H. D. Katzberg;MD (University of Toronto;Toronto Canada);L. Kiers;MD (University of Melbourne;Royal Melbourne Hospital;Parkville Australia);B. C. Kieseier;MD (Heinrich Heine University;Düsseldorf Germany);K. Kimpinski;MD (University Hospital;LHSC London-Ontario;Canada);S. Kuwabara;MD;PhD (Chiba University;Chiba Japan);J. Y. Kwan;MD (University of Maryland School of Medicine;Baltimore USA);S. S. Ladha;MD (Barrow Neurology Clinics;Phoenix Arizona;USA);V. Lawson;MD (Wexner Medical Center at The Ohio State University;Columbus USA);H. Lehmann;MD;PhD (University Hospital of Cologne;Universitätsklinikum Köln;Cologne Germany);H. Manji;MD;FRCP (Ipswich Hospital;Ipswich UK);G. A. Marfia;MD (Neurological Clinic;Policlinico Tor Vergata;Rome Italy);C. Márquez Infante;MD (Hospital Universitario Virgen del Rocio;Seville Spain);M. G. Mattiazzi;MD (Hospital Militar Central;Buenos Aires;Argentina);C. J. McDermott;MD (Royal Hallamshire Hospital;NIHR Clinical;Sheffield UK);M. S. Monges;MD (Hospital de Pediatría J. P. Garrahan;Buenos Aires;Argentina);G. Morís de la Tassa;MD (Hospital Universitario Central de Asturias;Asturias Spain);C. Nascimbene;MD;PhD (Luigi Sacco Hospital;Milan Italy);E. Nobile Orazio;MD;PhD (Milan University;Humanitas Clinicala and Research Institute Milan;Italy);R. J. Nowak;MD (Yale University School of Medicine;New Haven;USA);M. Osei-Bonsu (James Cook University Hospital;Middlesbrough UK);J. Pardo Fernandez (Hospital Clínico de Santiago;Santiago de Compostela (A Coruña);Spain);L. Querol Gutierrez;MD;PhD (Hospital de la Santa Creu i Sant Pau;Universitat Autònoma de Barcelona;Barcelona Spain);R. Reisin (Hospital Britanico;Buenos Aires;Argentina);S. Rinaldi;MBChB;PhD (University of Oxford R. C. Roberts;MD (Addenbrooke’s Hospital Cambridge;Cambridge UK);I. Rojas-Marcos;MD (Hospital Univesitario Reina Sofia;Cordoba Spain);S. A. Rudnicki;MD (University of Arkansas;Fayetteville USA);A. Schenone;MD;PhD (1. Department of Neurosciences;Rehabilitation Ophthalmology;Genetics and Maternal and Infantile Sciences (DINOGMI);University of Genova;Genova;Italy 2. IRCCS Policlinico San Martino;Genova Italy);M. J. Sedano Tous;MD (Hospital Universitario Marques de Valdecilla;Santander Cantabria;Spain);N. Shahrizaila;MD (Neurology Unit;Department of Medicine;Faculty of Medicine;University of Malaya;Malaya);K. Sheikh;MD;PhD (The University of Texas Health Science Center at Houston;Houston USA);N. J. Silvestri;MD (Buffalo General Medical Center;Buffalo NY;USA);C. L. Sommer;MD (Universitätsklinikum Würzburg;Würzburg Germany);J. D. Varrato;DO (Lehigh Valley Health Network;Allentown USA);J. Verschuuren;MD;PhD (Leiden University Medical Centre;Leiden;The Netherlands);M. V. Vytopil;MD;PhD (Tufts University School of Medicine Lahey Hospital W. Waheed;MD (University of Vermont Medical Center;Burlington USA);L. Zhou;MD;PhD (Icahn School of Medicine at Mount Sinai;New York;USA). Other collaborators were:U. A. Badrising;MD;PhD (Leiden University Medical Centre;Leiden;The Netherlands);I. R. Bella;MD (University of Mass Medical School;Worcester USA);C. Bunschoten;MD;PhD candidate (Erasmus University Medical Centre;Rotterdam;The Netherlands);J. Bürmann;MD;Universitätsklinikum des Saarlandes;Homburg Germany);M. Busby;MD (Leeds General Infirmary;Bradford UK);C. C. Chao;MD;PhD (National Taiwan University Hospital;Taipei Taiwan);M. E. Conti;MD (University Hospital Clinicas;Buenos Aires;Argentina);M. C. Dalakas;MD (1. Thomas Jefferson University;Philadelphia USA;2. National and Kapodistrian University of Athens;Athens Greece);P. Van Damme;MD;PhD (University Hospital Leuven;Leuven Belgium);A. Doets;MD;PhD candidate (Erasmus University Medical Centre;Rotterdam;the Netherlands);G. W. van Dijk;MD (Canisius Wilhelmina Hospital;Nijmegen;The Netherlands);M. M. Dimachkie;MD (University of Kansas Medical Center;Kansas City;USA);K. Doppler;MD (Universitätsklinikum Würzburg;Würzburg Germany);A. Echaniz-Laguna;MD (Hopital de Hautepierre;Strasbourgh France);F. Eftimov;MD;PhD (Amsterdam University Medical Centre;Amsterdam;The Netherlands);R. Fazio;MD (Scientific Institute San Raffaele;Milan Italy);C. Fokke;MD (Gelre Hospital;Zutphen and Apeldoorn;The Netherlands);E. A. Fulgenzi;MD (Hospital Cesar Milstein Buenos Aires;Buenos Aires;Argentina);M. P. J. Garssen;MD;PhD (Jeroen Bosch Hospital;’s Hertogenbosch;Zaltbommel and Drunen;The Netherlands);C. J. Gijsbers;MD (Vlietland Hospital;Schiedam;The Netherlands);J. Gilhuis;MD;PhD (Reinier de Graaf Gasthuis;Delft;The Netherlands);A. Grapperon;MD (CHU Timone;Marseille France);S. T. Hsieh;MD;PhD (National Taiwan University Hospital;Taipei Taiwan);I. Illa;MD;PhD (Hospital de la Santa Creu i Sant Pau;Universitat Autònoma de Barcelona;Barcelona Spain);B. Islam;MD;PhD (International Centre for Diarrhoeal Disease Research;Bangladesh (icddr;b) Dhaka;Bangladesh);K. Jellema;MD;PhD (Haaglanden Medisch Centrum;The Hague;The Netherlands);K. Kaida;MD;PhD (National Defense Medical College;Saitama Japan);N. Kokubun;MD (Dokkyo Medical University;Tochigi Japan);N. Kolb;MD (University of Vermont;Burlington VT;USA);R. van Koningsveld;MD;PhD (Elkerliek Hospital;Helmond and Deurne;The Netherlands);A. J. van der Kooi;MD;PhD (Amsterdam University Medical Centre;Amsterdam;The Netherlands);K. Kuitwaard;MD;PhD (Albert Schweitzer Hospital;Dordrecht;The Netherlands);L. Landschoff Lassen;MD (Glostrup Hospital;Glostrup Denmark);S. E. Leonhard;MD;PhD candidate (Erasmus University Medical Centre;Rotterdam;the Netherlands);M. Mandarakas;MD;PhD (Erasmus University Medical Centre;Rotterdam;the Netherlands);E. Martinez Hernandez;MD (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS);Hospital Clinic;Barcelona Spain);Q. D. Mohammad;MD;PhD (National Institute of Neurosciences and Hospital;Dhaka Bangladesh);M. Pulley;MD (University of Florida;Jacksonville USA);Y. A. Rajabally;MD;PhD (Queen Elizabeth Hospital;Birmingham UK);S. W. Reddel;MD;PhD (Concord Repatriation General Hospital;Sydney Australia);T. van der Ree;MD (Westfriesgasthuis;Hoorn;The Netherlands);J. Roodbol;MD;PhD candidate (Erasmus University Medical Centre;Rotterdam;the Netherlands);G. M. Sachs;MD (University of Rhode Island;Providence USA);J. P. A. Samijn;MD;PhD (Maasstad Hospital;Rotterdam;The Netherlands);L. Santoro;MD;PhD (University Federico II;Napels Italy);B. Stein;MD (St. Joseph’s Regional Medical Center;Paterson USA);F. H. Vermeij;MD (Franciscus Gasthuis;Rotterdam;The Netherlands);L. H. Visser;MD;PhD (Elisabeth-TweeSteden Hospital;Tilburg and Waalwijk;The Netherlands);H. J. Willison;MD;PhD (University of Glasgow;Glasgow UK);P. Wirtz;MD;PhD (HagaZiekenhuis;The Hague;The Netherlands);S. A. Zivkovich;MD;PhD (University of Pittsburgh Medical Center;Pittsburgh USA).
2020
Abstract
Objective To compare disease course in patients with Guillain-Barré syndrome (GBS) with a poor prognosis who were treated with one or with two intravenous immunoglobulin (IVIg) courses. Methods From the International GBS Outcome Study, we selected patients whose modified Erasmus GBS Outcome Score at week 1 predicted a poor prognosis. We compared those treated with one IVIg course to those treated with two IVIg courses. The primary endpoint, the GBS disability scale at 4 weeks, was assessed with multivariable ordinal regression. Results Of 237 eligible patients, 199 patients received a single IVIg course. Twenty patients received an α early' second IVIg course (1-2 weeks after start of the first IVIg course) and 18 patients a α late' second IVIg course (2-4 weeks after start of IVIg). At baseline and 1 week, those receiving two IVIg courses were more disabled than those receiving one course. Compared with the one course group, the adjusted OR for a better GBS disability score at 4 weeks was 0.70 (95%CI 0.16 to 3.04) for the early group and 0.66 (95%CI 0.18 to 2.50) for the late group. The secondary endpoints were not in favour of a second IVIg course. Conclusions This observational study did not show better outcomes after a second IVIg course in GBS with poor prognosis. The study was limited by small numbers and baseline imbalances. Lack of improvement was likely an incentive to start a second IVIg course. A prospective randomised trial is needed to evaluate whether a second IVIg course improves outcome in GBS.
01 Pubblicazione su rivista::01a Articolo in rivista
Second IVIg course in Guillain-Barré syndrome with poor prognosis. The non-randomised ISID study / C., Verboon; B., Van Den Berg; D. R., Cornblath; E., Venema; K. C., Gorson; M. P., Lunn; H., Lingsma; P., Van Den Bergh; T., Harbo; K., Bateman; Y., Pereon; So. H., Sindrup; S., Kusunoki; J., Miller; Z., Islam; H. -P., Hartung; G., Chavada; B. C., Jacobs; R. A. C., Hughes; Addington, Van Doorn P. A. J. M.; (University of Virginia, Md; USA), Charlottesville; on October 7, S. Consortia. Protected by copyright.; Downloaded from 8 Verboon C, 2019 at Uppsala Universitet BIBSAM http://jnnp. bmj. com/ J Neurol Neurosurg Psychiatry: first published as 10. 1136/jnnp-2019-321496 on 5 October 2019.; J Neurol Neurosurg Psychiatry 2019, et al.; 1136/jnnp-2019-321496 Neuromuscular Ajroud-Driss, 0:1–9. doi:10.; (Northwestern University Feinberg, Md; USA), Chicago; Antonini, G.; (Mental Health and Sensory Organs (NESMOS), Md; University, Sapienza; Hospital, Sant’Andrea; Italy), Rome; Attarian, S.; Md, ; (CHU Timone, Phd; France), Marseille; Barroso, F. A.; (Instituto de Investigaciones Neurológicas Raúl Carrea, Md; Fleni, ; Aires, Buenos; Argentina), ; Benedetti, L.; Md, ; (Ospedale Sant’ Andrea La Spezia, Phd; Spezia, La; Italy), ; Bertorini, T. E.; (The University of Tennessee Health Science Center (UTHSC), Md; USA), Memphis; Brannagan, T. H.; (Columbia University, Md; York City, New; USA), ; Briani, C.; (University of Padova, Md; Italy), Padova; Bhavaraju-Sanka, R.; (University Hospital/University of Texas Health Science Center, Md; Antonio Texas, San; USA), ; Butterworth, S.; (Pinderfields Hospital, Md; UK), Wakefield; Casasnovas, C.; Md, ; Ciberer, PhD (Bellvitge University Hospital – IDIBELL Neurometabolic Diseases Group.; Spain), Barcelona; Cavaletti, G.; (University Milano-Bicocca, Md; Italy), Monza; Chen, S.; Md, ; (Rutgers, Phd; Wood Johnson University Hospital, Robert; Brunswick, New; USA), ; Claeys, K. G.; Md, ; University Hospitals Leuven, PhD (1.; Belgium, Leuven; KU Leuven, 2.; Belgium), Leuven; Cosgrove, J. S.; (Leeds General Infirmary, Md; UK), Leeds; Davidson, A.; (University of Glasgow, Md; UK), Glasgow; Dardiotis, E.; (University of Thessaly, Md; of Larissa, Hospital; Greece), Larissa; Dornonville de la Cour, C.; (National Hospital Copenhagen, Md; Denmark), Copenhagen; Faber, C. G.; Md, ; (Maastricht University Medical Centre, Phd; Maastricht, ; Netherlands), The; Feasby, T. E.; (University of Calgary, Md; Canada), Calgary; Fujioka, T.; (Toho University Medical Center, Md; Japan), Tokyo; Galassi, G.; (University Hospital of Modena, Md; Italy), Modena; Gilchrist, J. M.; (Soulthern Illinois University School of Medicine, Md; USA), Springfield; Goyal, N. A.; (University of California, Md; USA), Irvine; Granit, V.; (Montefiore Medical, Md; Center, ; York, New; USA), ; Gutiérrez-Gutiérrez, G.; (Hospital Universitario Infanta Sofia, Md; Sebastian, San; Spain), ; Hadden, R. D. M.; Md, ; (King’s College Hospital, Phd; UK), London; Holt, J. K. L.; Phd, ; (The Walton Centre, Frcp; UK), Liverpool; Htut, M.; George’s Hospital, MD (St.; UK), London; Jericó Pascual, I.; Md, ; (Complejo Hospitalario de Navarra, Phd; Spain), Pamplona; Karafiath, S.; (University of Utah School of Medicine, Md; Lake City, Salt; USA), ; Katzberg, H. D.; (University of Toronto, Md; Canada), Toronto; Kiers, L.; (University of Melbourne, Md; Melbourne Hospital, Royal; Australia), Parkville; Kieseier, B. C.; (Heinrich Heine University, Md; Germany), Düsseldorf; Kimpinski, K.; (University Hospital, Md; London-Ontario, Lhsc; Canada), ; Kuwabara, S.; Md, ; (Chiba University, Phd; Japan), Chiba; Kwan, J. Y.; (University of Maryland School of Medicine, Md; USA), Baltimore; Ladha, S. S.; (Barrow Neurology Clinics, Md; Arizona, Phoenix; USA), ; Lawson, V.; (Wexner Medical Center at The Ohio State University, Md; USA), Columbus; Lehmann, H.; Md, ; (University Hospital of Cologne, Phd; Köln, Universitätsklinikum; Germany), Cologne; Manji, H.; Md, ; (Ipswich Hospital, Frcp; UK), Ipswich; Marfia, G. A.; (Neurological Clinic, Md; Tor Vergata, Policlinico; Italy), Rome; Márquez Infante, C.; (Hospital Universitario Virgen del Rocio, Md; Spain), Seville; Mattiazzi, M. G.; (Hospital Militar Central, Md; Aires, Buenos; Argentina), ; Mcdermott, C. J.; (Royal Hallamshire Hospital, Md; Clinical, Nihr; UK), Sheffield; Monges, M. S.; Garrahan, MD (Hospital de Pediatría J. P.; Aires, Buenos; Argentina), ; Morís de la Tassa, G.; (Hospital Universitario Central de Asturias, Md; Spain), Asturias; Nascimbene, C.; Md, ; (Luigi Sacco Hospital, Phd; Italy), Milan; Nobile Orazio, E.; Md, ; (Milan University, Phd; Clinicala and Research Institute Milan, Humanitas; Italy), ; Nowak, R. J.; (Yale University School of Medicine, Md; Haven, New; USA), ; Osei-Bonsu (James Cook University Hospital, M.; UK), Middlesbrough; Pardo Fernandez (Hospital Clínico de Santiago, J.; de Compostela (A Coruña), Santiago; Spain), ; Querol Gutierrez, L.; Md, ; i Sant Pau, PhD (Hospital de la Santa Creu; Autònoma de Barcelona, Universitat; Spain), Barcelona; Reisin (Hospital Britanico, R.; Aires, Buenos; Argentina), ; Rinaldi, S.; Mbchb, ; Roberts, PhD (University of Oxford R. C.; (Addenbrooke’s Hospital Cambridge, Md; UK), Cambridge; Rojas-Marcos, I.; (Hospital Univesitario Reina Sofia, Md; Spain), Cordoba; Rudnicki, S. A.; (University of Arkansas, Md; USA), Fayetteville; Schenone, A.; Md, ; Department of Neurosciences, PhD (1.; Ophthalmology, Rehabilitation; and Maternal and Infantile Sciences (DINOGMI), Genetics; of Genova, University; Genova, ; IRCCS Policlinico San Martino, Italy 2.; Italy), Genova; Sedano Tous, M. J.; (Hospital Universitario Marques de Valdecilla, Md; Cantabria, Santander; Spain), ; Shahrizaila, N.; (Neurology Unit, Md; of Medicine, Department; of Medicine, Faculty; of Malaya, University; Malaya), ; Sheikh, K.; Md, ; (The University of Texas Health Science Center at Houston, Phd; USA), Houston; Silvestri, N. J.; (Buffalo General Medical Center, Md; Ny, Buffalo; USA), ; Sommer, C. L.; (Universitätsklinikum Würzburg, Md; Germany), Würzburg; Varrato, J. D.; (Lehigh Valley Health Network, Do; USA), Allentown; Verschuuren, J.; Md, ; (Leiden University Medical Centre, Phd; Leiden, ; Netherlands), The; Vytopil, M. V.; Md, ; Waheed, PhD (Tufts University School of Medicine Lahey Hospital W.; (University of Vermont Medical Center, Md; USA), Burlington; Zhou, L.; Md, ; (Icahn School of Medicine at Mount Sinai, Phd; York, New; Badrising, USA). Other collaborators were:U. A.; Md, ; (Leiden University Medical Centre, Phd; Leiden, ; Netherlands), The; Bella, I. R.; (University of Mass Medical School, Md; USA), Worcester; Bunschoten, C.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Bürmann, J.; Md, ; des Saarlandes, Universitätsklinikum; Germany), Homburg; Busby, M.; (Leeds General Infirmary, Md; UK), Bradford; Chao, C. C.; Md, ; (National Taiwan University Hospital, Phd; Taiwan), Taipei; Conti, M. E.; (University Hospital Clinicas, Md; Aires, Buenos; Argentina), ; Dalakas, M. C.; Thomas Jefferson University, MD (1.; Usa, Philadelphia; National and Kapodistrian University of Athens, 2.; Greece), Athens; Van Damme, P.; Md, ; (University Hospital Leuven, Phd; Belgium), Leuven; Doets, A.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; van Dijk, G. W.; (Canisius Wilhelmina Hospital, Md; Nijmegen, ; Netherlands), The; Dimachkie, M. M.; (University of Kansas Medical Center, Md; City, Kansas; USA), ; Doppler, K.; (Universitätsklinikum Würzburg, Md; Germany), Würzburg; Echaniz-Laguna, A.; (Hopital de Hautepierre, Md; France), Strasbourgh; Eftimov, F.; Md, ; (Amsterdam University Medical Centre, Phd; Amsterdam, ; Netherlands), The; Fazio, R.; (Scientific Institute San Raffaele, Md; Italy), Milan; Fokke, C.; (Gelre Hospital, Md; and Apeldoorn, Zutphen; Netherlands), The; Fulgenzi, E. A.; (Hospital Cesar Milstein Buenos Aires, Md; Aires, Buenos; Argentina), ; Garssen, M. P. J.; Md, ; (Jeroen Bosch Hospital, Phd; Hertogenbosch, ’S; and Drunen, Zaltbommel; Netherlands), The; Gijsbers, C. J.; (Vlietland Hospital, Md; Schiedam, ; Netherlands), The; Gilhuis, J.; Md, ; (Reinier de Graaf Gasthuis, Phd; Delft, ; Netherlands), The; Grapperon, A.; (CHU Timone, Md; France), Marseille; Hsieh, S. T.; Md, ; (National Taiwan University Hospital, Phd; Taiwan), Taipei; Illa, I.; Md, ; i Sant Pau, PhD (Hospital de la Santa Creu; Autònoma de Barcelona, Universitat; Spain), Barcelona; Islam, B.; Md, ; (International Centre for Diarrhoeal Disease Research, Phd; (icddr, Bangladesh; Dhaka, b); Bangladesh), ; Jellema, K.; Md, ; (Haaglanden Medisch Centrum, Phd; Hague, The; Netherlands), The; Kaida, K.; Md, ; (National Defense Medical College, Phd; Japan), Saitama; Kokubun, N.; (Dokkyo Medical University, Md; Japan), Tochigi; Kolb, N.; (University of Vermont, Md; Vt, Burlington; USA), ; van Koningsveld, R.; Md, ; (Elkerliek Hospital, Phd; and Deurne, Helmond; Netherlands), The; van der Kooi, A. J.; Md, ; (Amsterdam University Medical Centre, Phd; Amsterdam, ; Netherlands), The; Kuitwaard, K.; Md, ; (Albert Schweitzer Hospital, Phd; Dordrecht, ; Netherlands), The; Landschoff Lassen, L.; (Glostrup Hospital, Md; Denmark), Glostrup; Leonhard, S. E.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Mandarakas, M.; Md, ; (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Martinez Hernandez, E.; i Sunyer (IDIBAPS), MD (Institut d’Investigacions Biomèdiques August Pi; Clinic, Hospital; Spain), Barcelona; Mohammad, Q. D.; Md, ; (National Institute of Neurosciences and Hospital, Phd; Bangladesh), Dhaka; Pulley, M.; (University of Florida, Md; USA), Jacksonville; Rajabally, Y. A.; Md, ; (Queen Elizabeth Hospital, Phd; UK), Birmingham; Reddel, S. W.; Md, ; (Concord Repatriation General Hospital, Phd; Australia), Sydney; van der Ree, T.; (Westfriesgasthuis, Md; Hoorn, ; Netherlands), The; Roodbol, J.; Md, ; candidate (Erasmus University Medical Centre, Phd; Rotterdam, ; Netherlands), The; Sachs, G. M.; (University of Rhode Island, Md; USA), Providence; Samijn, J. P. A.; Md, ; (Maasstad Hospital, Phd; Rotterdam, ; Netherlands), The; Santoro, L.; Md, ; (University Federico II, Phd; Italy), Napels; Stein, B.; Joseph’s Regional Medical Center, MD (St.; USA), Paterson; Vermeij, F. H.; (Franciscus Gasthuis, Md; Rotterdam, ; Netherlands), The; Visser, L. H.; Md, ; (Elisabeth-TweeSteden Hospital, Phd; and Waalwijk, Tilburg; Netherlands), The; Willison, H. J.; Md, ; (University of Glasgow, Phd; UK), Glasgow; Wirtz, P.; Md, ; (HagaZiekenhuis, Phd; Hague, The; Netherlands), The; Zivkovich, S. A.; Md, ; (University of Pittsburgh Medical Center, Phd; USA)., Pittsburgh. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - 91:2(2020), pp. 1-9. [10.1136/jnnp-2019-321496]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1509595
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
