Bone remodelling is a complex mechanism regulated by osteoclasts and osteoblasts and perturbation of this process leads to the onset of diseases, which may be characterized by altered bone erosion or formation. In this review we will describe some bone formation-related disorders as Sclerosteosis, Van Buchem disease, Hypophosphatasia and Camurati-Engelmann disease. In the past decades the research focused on these rare disorders offered the opportunity to understand important pathways regulating bone formation. Thus, the identification of the molecular defects behind the etiopathology of these diseases will open the way for new therapeutic approaches applicable also to the management of more common bone diseases including osteoporosis.

Looking for new anabolic treatment from rare diseases of bone formation / Rossi, Michela; Battafarano, Giulia; De Martino, Viviana; Scillitani, Alfredo; Minisola, Salvatore; Del Fattore, Andrea. - In: JOURNAL OF ENDOCRINOLOGY. - ISSN 0022-0795. - 248:2(2021), pp. R29-R40. [10.1530/JOE-20-0285]

Looking for new anabolic treatment from rare diseases of bone formation

De Martino, Viviana;Minisola, Salvatore
Penultimo
;
2021

Abstract

Bone remodelling is a complex mechanism regulated by osteoclasts and osteoblasts and perturbation of this process leads to the onset of diseases, which may be characterized by altered bone erosion or formation. In this review we will describe some bone formation-related disorders as Sclerosteosis, Van Buchem disease, Hypophosphatasia and Camurati-Engelmann disease. In the past decades the research focused on these rare disorders offered the opportunity to understand important pathways regulating bone formation. Thus, the identification of the molecular defects behind the etiopathology of these diseases will open the way for new therapeutic approaches applicable also to the management of more common bone diseases including osteoporosis.
2021
-bone diseases; osteoblast; bone formation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Looking for new anabolic treatment from rare diseases of bone formation / Rossi, Michela; Battafarano, Giulia; De Martino, Viviana; Scillitani, Alfredo; Minisola, Salvatore; Del Fattore, Andrea. - In: JOURNAL OF ENDOCRINOLOGY. - ISSN 0022-0795. - 248:2(2021), pp. R29-R40. [10.1530/JOE-20-0285]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1509304
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