The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term “hyperferritinemic syndromes” and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and “hyperferritinemic syndromes” are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and “hyperferritinemic syndromes” which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.

COVID-19 gone bad. a new character in the spectrum of the hyperferritinemic syndrome / Colafrancesco, S.; Alessandri, C.; Conti, F.; Priori, R.. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 19:7(2020). [10.1016/j.autrev.2020.102573]

COVID-19 gone bad. a new character in the spectrum of the hyperferritinemic syndrome

Colafrancesco S.;Alessandri C.;Conti F.
;
Priori R.
2020

Abstract

The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term “hyperferritinemic syndromes” and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and “hyperferritinemic syndromes” are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and “hyperferritinemic syndromes” which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1506377
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