The understanding of the biological substrates regulating feeding behavior is relevant to address the health problems related to food overconsumption. Several studies have expanded the conventional view of the homeostatic regulation of body weight mainly orchestrated by the hypothalamus, to include also the non-homeostatic control of appetite. Such processes include food reward and are mainly coordinated by the activation of the central mesolimbic dopaminergic pathway. The identification of endogenous systems acting as a bridge between homoeostatic and non-homeostatic pathways might represent a significant step toward the development of drugs for the treatment of aberrant eating patterns. Oxytocin is a hypothalamic hormone that is directly secreted into the brain and reaches the blood circulation through the neurohypophysis. Oxytocin regulates a variety of physiologic functions, including eating and metabolism. In the last years both preclinical and clinical studies well characterized oxytocin for its effects in reducing food intake and body weight. In the present review we summarize the role played by oxytocin in the control of both homeostatic and non-homeostatic eating, within cognitive, metabolic and reward mechanisms, to mostly highlight its potential therapeutic effects as a new pharmacological approach for the development of drugs for eating disorders. We conclude that the central oxytocinergic system is possibly one of the mechanisms that coordinate energy balance at the crossroads between homeostatic and non-homeostatic mechanisms. This concept should foster studies aimed at exploring the possible exploitation of oxytocin in the treatment of aberrant eating patterns.
Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals / Romano, A.; Friuli, M.; Cifani, C.; Gaetani, S.. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 171(2020), p. 108082.
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|Titolo:||Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals|
FRIULI, MARZIA (Secondo)
GAETANI, SILVANA (Ultimo)
|Data di pubblicazione:||2020|
|Citazione:||Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals / Romano, A.; Friuli, M.; Cifani, C.; Gaetani, S.. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 171(2020), p. 108082.|
|Appartiene alla tipologia:||01g Articolo di rassegna (Review)|