Mitochondria are multifaceted organelles representing the ‘powerhouse of cells’ for their function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in the regulation of innate and adaptive immune responses, including host defences against viruses, as well as in in- flammatory responses. This peculiar role of mitochondria is principally because of the activation of adaptor mitochon- drial proteins, known as mitochondrial antiviral signalling (MAVS) proteins. MAVS senses viral RNA and triggers the activation of the transcription factor NF-kB or IFN pathways and autophagy, in order to clear the infection and avoid exces- sive inflammation respectively.

Sex differences in antiviral immunity in SARS-CoV-2 infection. Mitochondria and mitomiR come into view / Iessi, Eliisabetta; Cittadini, Camilla; Anticoli, Simona; Fecchi, Katia; Matarrese, Paola; Ruggieri, Anna. - In: ACTA PHYSIOLOGICA. - ISSN 1748-1708. - 231:2(2021), pp. 1-3. [10.1111/apha.13571]

Sex differences in antiviral immunity in SARS-CoV-2 infection. Mitochondria and mitomiR come into view

Camilla Cittadini;
2021

Abstract

Mitochondria are multifaceted organelles representing the ‘powerhouse of cells’ for their function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in the regulation of innate and adaptive immune responses, including host defences against viruses, as well as in in- flammatory responses. This peculiar role of mitochondria is principally because of the activation of adaptor mitochon- drial proteins, known as mitochondrial antiviral signalling (MAVS) proteins. MAVS senses viral RNA and triggers the activation of the transcription factor NF-kB or IFN pathways and autophagy, in order to clear the infection and avoid exces- sive inflammation respectively.
2021
sars-cov-2 infection; mitomir
01 Pubblicazione su rivista::01m Editorial/Introduzione in rivista
Sex differences in antiviral immunity in SARS-CoV-2 infection. Mitochondria and mitomiR come into view / Iessi, Eliisabetta; Cittadini, Camilla; Anticoli, Simona; Fecchi, Katia; Matarrese, Paola; Ruggieri, Anna. - In: ACTA PHYSIOLOGICA. - ISSN 1748-1708. - 231:2(2021), pp. 1-3. [10.1111/apha.13571]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1500109
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