The reciprocal interaction in between theca (TCs) and granulosa (GCs) cells plays a pivotal role in al-lowing ovary to display a wide range of physiological functions, including steroidogenesis and reproduction capabilities. For instance, changes in the respective proportion among GCs and TCS have been correlated to progression or recovery from Polycystic Ovary Syn-drome (Bevilacqua, et al. 2019). To investigate how these cells cooperate, it is important to understand how they work in isolation. Therefore, segregation of the two cell clusters constitutes a pre-requisite for planning functional studies on the ovary.

A challenging task—how to successfully separate theca and granulosa cells: a mandatory step for investigating ovary steroidogenesis / Fedeli, Valeria; Monti, Noemi; Canipari, Rita. - In: ORGANISMS. - ISSN 2532-5876. - 4:1(2020), pp. 86-89. [10.13133/2532-5876/16965]

A challenging task—how to successfully separate theca and granulosa cells: a mandatory step for investigating ovary steroidogenesis

Valeria Fedeli
;
Noemi Monti;Rita Canipari
2020

Abstract

The reciprocal interaction in between theca (TCs) and granulosa (GCs) cells plays a pivotal role in al-lowing ovary to display a wide range of physiological functions, including steroidogenesis and reproduction capabilities. For instance, changes in the respective proportion among GCs and TCS have been correlated to progression or recovery from Polycystic Ovary Syn-drome (Bevilacqua, et al. 2019). To investigate how these cells cooperate, it is important to understand how they work in isolation. Therefore, segregation of the two cell clusters constitutes a pre-requisite for planning functional studies on the ovary.
2020
theca cells; granulosa cells; primary cultures; isolation method
01 Pubblicazione su rivista::01a Articolo in rivista
A challenging task—how to successfully separate theca and granulosa cells: a mandatory step for investigating ovary steroidogenesis / Fedeli, Valeria; Monti, Noemi; Canipari, Rita. - In: ORGANISMS. - ISSN 2532-5876. - 4:1(2020), pp. 86-89. [10.13133/2532-5876/16965]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1499669
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