BACKGROUND: Frailty is an age-related status of increased vulnerability to stressors caused by the accumulation of multiple health deficits. This construct may allow to capture the clinical complexity of patients with multiple sclerosis (MS).OBJECTIVE: To investigate the relationship between frailty and the clinical manifestations of MS.METHODS: Patients with MS were consecutively enrolled at five tertiary dedicated services. Disability and fatigue were assessed. The phenotypes of MS were also identified. Frailty was measured using a frailty index (FI), computed by cumulatively considering 42 age-related multidimensional health deficits.RESULTS: Overall, 745 MS patients (mean age=48.2years, standard deviation=11.7years; women 68%) were considered. The median FI value was 0.12 (interquartile range=0.05-0.19) and the 99th percentile was 0.40. FI scores were associated with MS disease duration, disability, fatigue, as well as with the number of previous disease-modifying treatments and current symptomatic therapies. A logistic regression analysis model showed that FI score was independently associated with the secondary progressive phenotype.CONCLUSION: Frailty is significantly associated with major characteristics of MS. The findings of the present cross-sectional investigation should be explored in future longitudinal studies.

Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation / Belvisi, Daniele; Canevelli, Marco; Baione, Viola; Buscarinu, Maria Chiara; Pellicciari, Giulia; Fantozzi, Roberta; Creta, Armando; Cecchi, Gianluca; Cola, Gaia; Nicoletti, Carolina Gabri; Cortese, Antonio; De Giglio, Laura; Tartaglia, Matteo; Crisafulli, Sebastiano Giuseppe; Bruno, Giuseppe; Ferraro, Elisabetta; Marfia, Girolama Alessandra; Centonze, Diego; Salvetti, Marco; Conte, Antonella. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - (2021), p. 1352458520987541. [10.1177/1352458520987541]

Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation

Belvisi, Daniele;Canevelli, Marco;Baione, Viola;Buscarinu, Maria Chiara;Pellicciari, Giulia;Cortese, Antonio;De Giglio, Laura;Tartaglia, Matteo;Crisafulli, Sebastiano Giuseppe;Bruno, Giuseppe;Salvetti, Marco;Conte, Antonella
2021

Abstract

BACKGROUND: Frailty is an age-related status of increased vulnerability to stressors caused by the accumulation of multiple health deficits. This construct may allow to capture the clinical complexity of patients with multiple sclerosis (MS).OBJECTIVE: To investigate the relationship between frailty and the clinical manifestations of MS.METHODS: Patients with MS were consecutively enrolled at five tertiary dedicated services. Disability and fatigue were assessed. The phenotypes of MS were also identified. Frailty was measured using a frailty index (FI), computed by cumulatively considering 42 age-related multidimensional health deficits.RESULTS: Overall, 745 MS patients (mean age=48.2years, standard deviation=11.7years; women 68%) were considered. The median FI value was 0.12 (interquartile range=0.05-0.19) and the 99th percentile was 0.40. FI scores were associated with MS disease duration, disability, fatigue, as well as with the number of previous disease-modifying treatments and current symptomatic therapies. A logistic regression analysis model showed that FI score was independently associated with the secondary progressive phenotype.CONCLUSION: Frailty is significantly associated with major characteristics of MS. The findings of the present cross-sectional investigation should be explored in future longitudinal studies.
2021
Multiple sclerosis; disability; fatigue; frailty; risk profile; secondary progressive multiple sclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation / Belvisi, Daniele; Canevelli, Marco; Baione, Viola; Buscarinu, Maria Chiara; Pellicciari, Giulia; Fantozzi, Roberta; Creta, Armando; Cecchi, Gianluca; Cola, Gaia; Nicoletti, Carolina Gabri; Cortese, Antonio; De Giglio, Laura; Tartaglia, Matteo; Crisafulli, Sebastiano Giuseppe; Bruno, Giuseppe; Ferraro, Elisabetta; Marfia, Girolama Alessandra; Centonze, Diego; Salvetti, Marco; Conte, Antonella. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - (2021), p. 1352458520987541. [10.1177/1352458520987541]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1496781
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