We report the case of a 78-year-old woman with a history of surgical excision of vulvar melanoma (VM; stage IV c-Kitex-17 mutated) who developed lung and nodal metastases, achieving 9- month complete response from anti-PD1 MoAb. She gave written consent for this publication; ethics committee approvalwaswaived because of the case report format. Subsequently, the onset of fatigue associated with severe anemia (up to Hb 7.5 g/dL) occurred. Gastroscopy, colonoscopy, and hematologic investigations, such as bone marrow biopsy, were negative. The computed tomography scan showed an unspecific dilatation of the small bowel loops without air fluid levels. Based on these findings, she underwent video capsule endoscopy, showing an irregular, hyperemic, bloody, and pigmented ulcer of the first jejunal loop.

Severe anemia in a patient with vulvar melanoma / Tucci, M; Pasculli, A; Sgaramella, Li; Cazzato, G; Macorano, E; Piscitelli, D; Gurrado, A; Testini, M. - In: SURGERY. - ISSN 0039-6060. - 168:issue 5(2020), pp. e21-e22. [10.1016/j.surg.2020.07.017]

Severe anemia in a patient with vulvar melanoma

Sgaramella LI
Writing – Review & Editing
;
Testini M
Conceptualization
2020

Abstract

We report the case of a 78-year-old woman with a history of surgical excision of vulvar melanoma (VM; stage IV c-Kitex-17 mutated) who developed lung and nodal metastases, achieving 9- month complete response from anti-PD1 MoAb. She gave written consent for this publication; ethics committee approvalwaswaived because of the case report format. Subsequently, the onset of fatigue associated with severe anemia (up to Hb 7.5 g/dL) occurred. Gastroscopy, colonoscopy, and hematologic investigations, such as bone marrow biopsy, were negative. The computed tomography scan showed an unspecific dilatation of the small bowel loops without air fluid levels. Based on these findings, she underwent video capsule endoscopy, showing an irregular, hyperemic, bloody, and pigmented ulcer of the first jejunal loop.
File allegati a questo prodotto
File Dimensione Formato  
Tucci_Anemia-vulvar-melanoma_2020.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 991.8 kB
Formato Adobe PDF
991.8 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1495903
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 1
social impact