The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor naïve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.

Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation / Lucarelli, B.; Merli, P.; Bertaina, V.; Locatelli, F.. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-666X. - 12:3(2016), pp. 343-358. [10.1586/1744666X.2016.1123091]

Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation

Locatelli F.
2016

Abstract

The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor naïve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.
2016
donor leukocyte infusion; hematopoietic stem cell transplantation; Immune reconstitution; T-cell immunotherapy; thymus function
01 Pubblicazione su rivista::01a Articolo in rivista
Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation / Lucarelli, B.; Merli, P.; Bertaina, V.; Locatelli, F.. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-666X. - 12:3(2016), pp. 343-358. [10.1586/1744666X.2016.1123091]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1487578
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