Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, suggesting a block of the viral particles release from the infected cells.
Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity / Zippilli, C., Botta, L., Mattia Bizzarri, B., Nencioni, L., De Angelis, M., Protto, V., Giorgi, G., Camilla Baratto, M., Pogni, R., Saladino, R.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:3(2021), pp. 1-14. [10.3390/ijms22031337]
Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity
Lucia Nencioni;Marta De Angelis;Virginia Protto;Raffaele Saladino
2021
Abstract
Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, suggesting a block of the viral particles release from the infected cells.| File | Dimensione | Formato | |
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