Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, suggesting a block of the viral particles release from the infected cells.
Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity / Zippilli, Claudio; Botta, Lorenzo; Mattia Bizzarri, Bruno; Nencioni, Lucia; De Angelis, Marta; Protto, Virginia; Giorgi, Gianluca; Camilla Baratto, Maria; Pogni, Rebecca; Saladino, Raffaele. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:3(2021), pp. 1-14. [10.3390/ijms22031337]
Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity
Lucia Nencioni;Marta De Angelis;Virginia Protto;
2021
Abstract
Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, suggesting a block of the viral particles release from the infected cells.| File | Dimensione | Formato | |
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