Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
The interplay between angiopoietin-like proteins and adipose tissue: Another piece of the relationship between adiposopathy and cardiometabolic diseases? / Bini, S.; D'Erasmo, L.; Di Costanzo, A.; Minicocci, I.; Pecce, V.; Arca, M.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:2(2021), pp. 1-16. [10.3390/ijms22020742]
The interplay between angiopoietin-like proteins and adipose tissue: Another piece of the relationship between adiposopathy and cardiometabolic diseases?
Bini S.
Co-primo
Writing – Original Draft Preparation
;D'Erasmo L.
Co-primo
Writing – Review & Editing
;Di Costanzo A.Secondo
Membro del Collaboration Group
;Minicocci I.Membro del Collaboration Group
;Pecce V.Membro del Collaboration Group
;Arca M.Ultimo
Conceptualization
2021
Abstract
Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
