Background: Photodynamic therapy (PDT) represents an optimal treatment for basal cell carcinoma (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that has been applied in skin oncology and for BCC diagnosis. Moreover, RCM is a useful tool to determine noninvasive treatment efficacy of nonmelanoma skin cancer. Objective: We aimed to investigate the role of RCM in assessing the efficacy of PDT in the treatment of BCC and to evaluate the skin changes following the PDT. Methods: Ten patients with 12 BCCs were treated with PDT. Dermoscopy and RCM imaging were performed at baseline as well as 7 days (T1), 30 days and 18 months after PDT. Cytological examination was taken at baseline and in case of BCC persistence. Results: At T1, RCM showed the presence of several dendritic-shaped cells within the epidermis, corresponding to activated Langerhans cells. After 1 month, RCM showed the persistence of 2 BCCs, which escaped the clinical and dermoscopic diagnosis. At the long-term follow-up, none of the tumors revealed signs of persistence or recurrence. Conclusion: RCM is a valuable noninvasive tool for the diagnosis and treatment monitoring of BCC using PDT.

Confocal microscopy insights into the treatment and cellular immune response of Basal cell carcinoma to photodynamic therapy / Longo, Caterina; Casari, A; Pepe, P; Moscarella, E; Zalaudek, I; Argenziano, G; Pellacani, Giovanni. - In: DERMATOLOGY. - ISSN 1051-8258. - 225(3):(2013), pp. 264-270. [10.1159/000345106]

Confocal microscopy insights into the treatment and cellular immune response of Basal cell carcinoma to photodynamic therapy

PELLACANI, Giovanni
2013

Abstract

Background: Photodynamic therapy (PDT) represents an optimal treatment for basal cell carcinoma (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that has been applied in skin oncology and for BCC diagnosis. Moreover, RCM is a useful tool to determine noninvasive treatment efficacy of nonmelanoma skin cancer. Objective: We aimed to investigate the role of RCM in assessing the efficacy of PDT in the treatment of BCC and to evaluate the skin changes following the PDT. Methods: Ten patients with 12 BCCs were treated with PDT. Dermoscopy and RCM imaging were performed at baseline as well as 7 days (T1), 30 days and 18 months after PDT. Cytological examination was taken at baseline and in case of BCC persistence. Results: At T1, RCM showed the presence of several dendritic-shaped cells within the epidermis, corresponding to activated Langerhans cells. After 1 month, RCM showed the persistence of 2 BCCs, which escaped the clinical and dermoscopic diagnosis. At the long-term follow-up, none of the tumors revealed signs of persistence or recurrence. Conclusion: RCM is a valuable noninvasive tool for the diagnosis and treatment monitoring of BCC using PDT.
2013
photodinamic therapy; basal cell carcinoma
01 Pubblicazione su rivista::01a Articolo in rivista
Confocal microscopy insights into the treatment and cellular immune response of Basal cell carcinoma to photodynamic therapy / Longo, Caterina; Casari, A; Pepe, P; Moscarella, E; Zalaudek, I; Argenziano, G; Pellacani, Giovanni. - In: DERMATOLOGY. - ISSN 1051-8258. - 225(3):(2013), pp. 264-270. [10.1159/000345106]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1483805
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