Toxicants of different classes were analysed for capacity to induce gene mutation and mitotic non-disjunction in Aspergillus nidulans, using selective and permissive tests, respectively. Ethanol, Amphotericin B and MIcanozole, all affecting membrane integrity, induced only non-disjunction, emphasizing the röle of the membrane in mitosis. Benomyl and isopropyl-3-chlorophenyl carbamate (CIPC), two pesticides which interfere with spindle system, induced only non-disjunction. Conversely, mitomycin C markedly increased mutation rate but not ono-disjunction and scarcely affected the viability. The comparative analysis of these two different genetic damages should prove useful in evaluating hazards of drugs.
Induced gene mutation and mitotic non-disjunction in A.nidulans / Gualandi, G; Bellincampi, Daniela. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 9:(1981), pp. 389-394. [10.1016/0378-4274(81)90015-1]
Induced gene mutation and mitotic non-disjunction in A.nidulans.
BELLINCAMPI, Daniela
1981
Abstract
Toxicants of different classes were analysed for capacity to induce gene mutation and mitotic non-disjunction in Aspergillus nidulans, using selective and permissive tests, respectively. Ethanol, Amphotericin B and MIcanozole, all affecting membrane integrity, induced only non-disjunction, emphasizing the röle of the membrane in mitosis. Benomyl and isopropyl-3-chlorophenyl carbamate (CIPC), two pesticides which interfere with spindle system, induced only non-disjunction. Conversely, mitomycin C markedly increased mutation rate but not ono-disjunction and scarcely affected the viability. The comparative analysis of these two different genetic damages should prove useful in evaluating hazards of drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
