Background Surgical excision represents the most common elective treatment for basal cell carcinoma (BCC). Several noninvasive approaches have been proposed for in vivo determination of tumour margin, in order to achieve radical removal. Objectives To propose a new approach through the combination of dermoscopy and reflectance confocal microscopy (RCM) for lateral margin detection in BCC. Methods Ten patients with lesions clinically suggestive of nonpigmented BCCs with ill-defined margins were enrolled. All BCCs were dermoscopically evaluated first and the ill-defined margins were marked with a superficial cut and then inspected using RCM. Results RCM evaluation showed BCC foci beyond the presurgical marker in three out of 10 lesions. Histology confirmed the RCM results: the presence of BCC features across the cut, corresponding to two superficial BCCs and a morpheaform BCC. Conclusions This new procedure helped to improve the identification of proper margins for surgical excision in nonpigmented BCC with clinically and dermoscopically ill-defined margins.

A new approach for presurgical margin assessment by reflectance confocal microscopy of basal cell carcinoma / Venturini, M; Gualdi, G; Zanca, A; Lorenzi, L; Pellacani, Giovanni; Calzavara Pinton, P. G.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 174:2(2016), pp. 380-385. [10.1111/bjd.14244]

A new approach for presurgical margin assessment by reflectance confocal microscopy of basal cell carcinoma

PELLACANI, Giovanni;
2016

Abstract

Background Surgical excision represents the most common elective treatment for basal cell carcinoma (BCC). Several noninvasive approaches have been proposed for in vivo determination of tumour margin, in order to achieve radical removal. Objectives To propose a new approach through the combination of dermoscopy and reflectance confocal microscopy (RCM) for lateral margin detection in BCC. Methods Ten patients with lesions clinically suggestive of nonpigmented BCCs with ill-defined margins were enrolled. All BCCs were dermoscopically evaluated first and the ill-defined margins were marked with a superficial cut and then inspected using RCM. Results RCM evaluation showed BCC foci beyond the presurgical marker in three out of 10 lesions. Histology confirmed the RCM results: the presence of BCC features across the cut, corresponding to two superficial BCCs and a morpheaform BCC. Conclusions This new procedure helped to improve the identification of proper margins for surgical excision in nonpigmented BCC with clinically and dermoscopically ill-defined margins.
2016
basal cell carcinoma; cancer margin; dermoscopy; in vivo reflectance confocal microscopy; surgical excision
01 Pubblicazione su rivista::01a Articolo in rivista
A new approach for presurgical margin assessment by reflectance confocal microscopy of basal cell carcinoma / Venturini, M; Gualdi, G; Zanca, A; Lorenzi, L; Pellacani, Giovanni; Calzavara Pinton, P. G.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 174:2(2016), pp. 380-385. [10.1111/bjd.14244]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1483698
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