Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram

Maurichi, Andrea; Miceli, Rosalba; Eriksson, Hanna; Newton-Bishop, Julia; Nsengimana, Jérémie; Chan, May; Hayes, Andrew J.; Heelan, Kara; Adams, David; Patuzzo, Roberto; Barretta, Francesco; Gallino, Gianfranco; Harwood, Catherine; Bergamaschi, Daniele; Bennett, Dorothy; Lasithiotakis, Konstantinos; Ghiorzo, Paola; Dalmasso, Bruna; Manganoni, Ausilia; Consoli, Francesca; Mattavelli, Ilaria; Barbieri, Consuelo; Leva, Andrea; Cortinovis, Umberto; Espeli, Vittoria; Mangas, Cristina; Quaglino, Pietro; Ribero, Simone; Broganelli, Paolo; Pellacani, Giovanni; Longo, Caterina; Del Forno, Corrado; Borgognoni, Lorenzo; Sestini, Serena; Pimpinelli, Nicola; Fortunato, Sara; Chiarugi, Alessandra; Nardini, Paolo; Morittu, Elena; Florita, Antonio; Cossa, Mara; Valeri, Barbara; Milione, Massimo; Pruneri, Giancarlo; Zoras, Odysseas; Anichini, Andrea; Mortarini, Roberta; Santinami, Mario

doi:10.1200/JCO.19.01902

Thin melanomas (T1; # 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma guidelines do not provide clear indications on when to perform SNB in T1 disease and stress an individualized approach to SNB that considers all clinicopathologic risk factors. We aimed to identify determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better select patients with T1 disease for SNB.

Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram / Maurichi, Andrea; Miceli, Rosalba; Eriksson, Hanna; Newton-Bishop, Julia; Nsengimana, Jérémie; Chan, May; Hayes, Andrew J.; Heelan, Kara; Adams, David; Patuzzo, Roberto; Barretta, Francesco; Gallino, Gianfranco; Harwood, Catherine; Bergamaschi, Daniele; Bennett, Dorothy; Lasithiotakis, Konstantinos; Ghiorzo, Paola; Dalmasso, Bruna; Manganoni, Ausilia; Consoli, Francesca; Mattavelli, Ilaria; Barbieri, Consuelo; Leva, Andrea; Cortinovis, Umberto; Espeli, Vittoria; Mangas, Cristina; Quaglino, Pietro; Ribero, Simone; Broganelli, Paolo; Pellacani, Giovanni; Longo, Caterina; Del Forno, Corrado; Borgognoni, Lorenzo; Sestini, Serena; Pimpinelli, Nicola; Fortunato, Sara; Chiarugi, Alessandra; Nardini, Paolo; Morittu, Elena; Florita, Antonio; Cossa, Mara; Valeri, Barbara; Milione, Massimo; Pruneri, Giancarlo; Zoras, Odysseas; Anichini, Andrea; Mortarini, Roberta; Santinami, Mario. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - 38:14(2020), pp. 1591-1601. [10.1200/JCO.19.01902]