Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children / Uden, T.; Bertaina, A.; Abrahamsson, J.; Ansari, M.; Balduzzi, A.; Bourquin, J. -P.; Gerhardt, C.; Bierings, M.; Hasle, H.; Lankester, A.; Mischke, K.; Moore, A. S.; Nivison-Smith, I.; Pieczonka, A.; Peters, C.; Sedlacek, P.; Reinhardt, D.; Stein, J.; Versluys, B.; Wachowiak, J.; Willems, L.; Zimmermann, M.; Locatelli, F.; Sauer, M. G.. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 189:4(2020), pp. 745-750. [10.1111/bjh.16441]
Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children
Locatelli F.;
2020
Abstract
Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.| File | Dimensione | Formato | |
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