Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019 / Bordoni, V., Sacchi, A., Cimini, E., Notari, S., Grassi, G., Tartaglia, E., Casetti, R., Giancola, M.L., Bevilacqua, N., Maeurer, M., Zumla, A., Locatelli, F., De Benedetti, F., Palmieri, F., Marchioni, L., Capobianchi, M.R., D'Offizi, G., Petrosillo, N., Antinori, A., Nicastri, E., et al.. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 71:16(2020), pp. 2272-2275. [10.1093/cid/ciaa577]
An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019
Locatelli F.;
2020
Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.| File | Dimensione | Formato | |
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