Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.
The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory / Grimsholm, O., Piano Mortari, E., Davydov, A.N., Shugay, M., Obraztsova, A.S., Bocci, C., Marasco, E., Marcellini, V., Aranburu, A., Farroni, C., Silvestris, D.A., Cristofoletti, C., Giorda, E., Scarsella, M., Cascioli, S., Barresi, S., Lougaris, V., Plebani, A., Cancrini, C., Finocchi, A., et al.. - In: CELL REPORTS. - ISSN 2211-1247. - 30:9(2020), pp. 2963-2977.e6. [10.1016/j.celrep.2020.02.022]
The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory
Piano Mortari E.;Locatelli F.;
2020
Abstract
Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.| File | Dimensione | Formato | |
|---|---|---|---|
|
Grimsholm_The-interplay_2020.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
5.14 MB
Formato
Adobe PDF
|
5.14 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
