Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.
The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory / Grimsholm, O.; Piano Mortari, E.; Davydov, A. N.; Shugay, M.; Obraztsova, A. S.; Bocci, C.; Marasco, E.; Marcellini, V.; Aranburu, A.; Farroni, C.; Silvestris, D. A.; Cristofoletti, C.; Giorda, E.; Scarsella, M.; Cascioli, S.; Barresi, S.; Lougaris, V.; Plebani, A.; Cancrini, C.; Finocchi, A.; Moschese, V.; Valentini, D.; Vallone, C.; Signore, F.; de Vincentiis, G.; Zaffina, S.; Russo, G.; Gallo, A.; Locatelli, F.; Tozzi, A. E.; Tartaglia, M.; Chudakov, D. M.; Carsetti, R.. - In: CELL REPORTS. - ISSN 2211-1247. - 30:9(2020), pp. 2963-2977.e6. [10.1016/j.celrep.2020.02.022]
The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory
Piano Mortari E.;Locatelli F.;
2020
Abstract
Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.| File | Dimensione | Formato | |
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