Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6- trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl- 4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1 (Sendai) virus replication.

A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives / Raffaele, Saladino; Maria Chiara, Danti; Mincione, Enrico; Claudia, Crestini; Palamara, ANNA TERESA; Patrizia, Savini; Marini, Stefano; Maurizio, Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 8:14(1998), pp. 1833-1838. [10.1016/s0960-894x(98)00314-x]

A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives

MINCIONE, Enrico;PALAMARA, ANNA TERESA;MARINI, Stefano;
1998

Abstract

Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6- trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl- 4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1 (Sendai) virus replication.
01 Pubblicazione su rivista::01a Articolo in rivista
A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives / Raffaele, Saladino; Maria Chiara, Danti; Mincione, Enrico; Claudia, Crestini; Palamara, ANNA TERESA; Patrizia, Savini; Marini, Stefano; Maurizio, Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 8:14(1998), pp. 1833-1838. [10.1016/s0960-894x(98)00314-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/14802
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